Airway dendritic cells (DCs) are held responsible for inducing sensitization to inhaled antigen, leading to eosinophilic airway inflammation, typical of asthma. However, less information is available about the role of these cells in ongoing inflammation. In a mouse model of asthma, sensitization to ovalbumin (OVA) was induced by intratracheal injection of myeloid OVA-pulsed DCs. Upon OVA aeroso...

Powerful radio galaxies often display enhanced optical/UV emission regions, elongated and aligned with the radio jet axis. The aim of this series of papers is to separately investigate the effects of radio power and redshift on the alignment effect, together with other radio galaxy properties. In this second paper, we present a deeper analysis of the morphological properties of these systems, i...

The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylatio...

BACKGROUND Although inflammation induces pain, immune cells also produce mediators that can effectively counteract it. To further elucidate the role of the immune response, we analyzed the relationship of pain behavior, several inflammatory signals, and opioid peptides using partial sciatic nerve ligation in mice at different levels of immunocompromise. METHODS Sciatic nerves of C57BL/6C, non...

The prevalence of Streptococcus pneumoniae serotype 6C, a recently recognized serotype that cross-reacts serologically with serotype 6A, was investigated. Isolates of serotype 6A in various collections were recovered, and serotype 6C was differentiated from 6A by multiplex PCR of DNA extracts by using appropriate primers. Antimicrobial susceptibility was performed by Clinical and Laboratory Sta...

OBJECTIVE Abdominal aortic aneurysm (AAA) is widespread among elderly people and results in progressive expansion and rupture of the aorta with high mortality. Macrophages, which are the main population observed within the site of aneurysm, are thought to derive from circulating monocytes although no direct evidence has been provided to date. In this study, we were particularly interested in un...

OBJECTIVES To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb)--6C and 30C--in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). METHODS Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As(2)O(3) (0.016%) injected at 1 ml/100 g body weight...

As part of our studies focused on the design and synthesis of new antimicrobial agents a series of 7-fluoro-3,4-dihydro-2H-1,4-benzothiazine derivatives (4a-4f, 4h) and 7-fluoro-2H-1,4-benzothiazin-3(4H)-one analogues (4j-4o) were synthesized and evaluated for their in vitro inhibitory activity against a representative panel of Gram-positive and Gram-negative bacteria strains and also toward se...

A Gram-stain-negative, aerobic, orange-pigmented bacterial strain, designated HHU K3-1 T, was isolated from the surface water of Yellow Sea. The strain observed to grow on 2216E agar medium, and growth occurred at pH 6.0–8.0 (optimum 7.0), 28–37 °C 28 °C), in presence 0.5–5% (w/v) NaCl 1–3%). major fatty acids (> 10%) were summed feature 3 (C16:1?6c/C16:1?7c), C17:1?6c 8 (C18:1?6c/C18:1?7c). St...