Postmarketing data about the effectiveness of zonisamide in childhood epilepsy was collected from 759 children with various forms of epilepsy (ages 3 months-15 years) to compare the long-term efficacy of zonisamide in the treatment of epilepsy in intellectually normal versus intellectually disabled children. The follow-up period was 6 months-3 years; 291 children (245 intellectually normal, 46 ...

Oncostatin M (OnM) signals through cell surface receptors, which utilize the gp130 subunit. In cultured human umbilical vein endothelial cells (HUVEC), OnM transiently elevates mRNA encoding for suppressor of cytokine signaling-3 (SOCS-3). By 1 h of OnM treatment, HUVEC become refractory to the restimulation by OnM, measured as failure to reinduce SOCS-3 mRNA. OnMinduced desensitization also pr...

OBJECTIVE To estimate and compare radiation exposure and intervention time during lumbar epidural steroid injection (ESI) 1) under different practitioners and methods with continuous fluoroscopic monitoring, and 2) under one practitioner with different methods and monitoring. MATERIALS AND METHODS We consecutively recruited 804 patients who underwent lumbar ESI and 759 patients who underwent ...

Previous studies have shown that mouse gamma F-crystallin sequences -759 to +45, which include the core promoter and two upstream enhancer elements, contain sufficient information for directing gene expression to terminally differentiated fiber cells of the ocular lens. To investigate the role that proximal sequences of the mouse gamma F-crystallin promoter play in the developmental regulation ...

Intramolecular communication within myosin is essential for its function as motor, but the specific amino acid residue interactions required are unexplored within muscle cells. Using Drosophila melanogaster skeletal muscle myosin, we performed a novel in vivo molecular suppression analysis to define the importance of three relay loop amino acid residues (Ile(508), Asn(509), and Asp(511)) in com...

BACKGROUND Cytology for breast lesions is a safe, rapid and cost-effective with a high specificity and sensitivity. OBJECTIVE To determine the cytomorphologic patterns of breast lesions identified among a group of Sudanese patients. MATERIALS AND METHODS This study included 759 patients undergoing either a fine needle aspiration FNA, nipple discharge (ND) smears or breast skin scraping (SS)...

Diaphanous homologue 1 (DIAPH1) is a Rho effector protein that coordinates cellular dynamics by regulating microfilament and microtubule function. We previously showed that DIAPH1 plays an integral role in regulating the production of cortisol by controlling the rate of mitochondrial movement, by which activation of the adrenocorticotropin (ACTH)/cAMP signaling pathway stimulates mitochondrial ...

(1 + 1) [278, 1816, 365, 1699]. (2 + 1) [507, 33, 487, 1110, 1492, 271]. (2m, 2n) [1307]. (2N) [1932]. (3/2) [591]. (5) [777]. (:φ: )2 [1788]. (dX/dx) + λX = 0 [1031]. (λ/4!)(φ1 + φ 4 2)d [813]. (M +N) [1110]. (n) [518]. (N + 1) [1932]. (n ≥ 2) [413]. (p, q) [1744]. (q, h) [573]. 1 + 1 [1100, 759]. 1/2 [642, 699]. 1/N [152]. 1/r [1160]. 1: 1: 2 [1943]. 2 [936, 1777, 1669, 1733, 1636]. 2 + 1 [71...