This first clinical prospective study was conducted to use of technetium-99m immunoglobulin G (99mTc-IgG) as compared with autologous 99mTc-red blood cells (RBC) in gated blood pool ventriculography. We studied 12 patients who referred to us for a possible diagnosis of liver hemangioma or infection. Six patients underwent gated planar blood pool (GPBP) acquisition using 99mTc-RBC and 6 GPBP acq...

BACKGROUND Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been p...

99mTc radiopharmaceuticals play an important role in widespread applications of nuclear medicine. When 99mTc radiopharmaceuticals first came into use, major efforts were directed toward the development of 99mTc radiopharmaceuticals for bone imaging and for the excretory functions of the liver and kidneys. In the past 20 years, a significant advance has been made in technetium chemistry, which p...

UNLABELLED Quantitative nuclear renography has numerous potential sources of error. We previously reported the initial development of a computer software module for comprehensively addressing the issue of quality control (QC) in the analysis of radionuclide renal images. The objective of this study was to prospectively test the QC software. METHODS The QC software works in conjunction with st...

OBJECTIVES To validate 99mTc-labeled arginylglycylaspartic acid (99mTc-3PRGD2) scintigraphy as a means to image synovial neoangiogenesis in joints afflicted by rheumatoid arthritis and to investigate its potential in the early detection and management of rheumatoid arthritis. METHODS Rheumatoid arthritis and osteoarthritis were generated in Sprague Dawley rats by type II collagen immunization...

The present study was conducted to evaluate radioimmunoimaging (RII) and in vivo distribution of mixed antibodies 99mTc-EGFR-mAb and 99mTc-CD44- mAb in nude mice bearing human lung adenocarcinoma xenografts. Single and mixed applications of the two radiolabeled monoclonal antibodies (mAbs) were compared. Direct labeling of 99mTc was applied to radiolabel the EGFR and CD44 mAbs. The properties o...

The Sandaozhuang super-large W-Mo deposit is located in the southern margin of North China Craton, within well-known East Qinling Mo mineralization belt, and one typical skarn-type deposits China. Based on EMPA LA-ICP-MS analyses, major trace elements were presented, mineral chemistry magnetite at various stages was discussed. Combining field observations, petrography, geochemical characteristi...

Treatment of advanced heart failure with implantable LVADs is increasing, driven by profound unmet patient need despite potential serious complications: bleeding, infection, and thrombus. The experimental objective was to develop a sensitive imaging approach to assess early thrombus accumulation in LVADs under operational high flow and high shear rates. Methods: A monomeric bifunctional ligand ...

Recent studies have suggested that technetium-99m (19mTc) MAG3 can be substituted for iodine-131 ( 131 I) OIH, with better image quality and lower radiation dose. This study compares the two radiopharmaceuticals for effective renal plasma flow (ERPF) results using only the camera method. Twenty patients with varying degrees of renal impairment were studied. In 13 of these patients, direct compa...

Recent studies have suggested that technetium-99m (19mTc) MAG3 can be substituted for iodine-131 ( 131 I) OIH, with better image quality and lower radiation dose. This study compares the two radiopharmaceuticals for effective renal plasma flow (ERPF) results using only the camera method. Twenty patients with varying degrees of renal impairment were studied. In 13 of these patients, direct compa...