The impact of repeated administration cinntamtannin A2 (A2, 25 μg/kg) on skeletal muscle disuse atrophy model mice induced by hindlimb suspension for 14 days was examined. In soleus, weight loss and a reduction in the average myofibre size with shifting to smaller side peak were observed suspension-vehicle group, but reduced these changes. Average significantly increased ground-A2 compared grou...

Enhancing factor (EF), a growth regulatory molecule, isolated from mouse small intestines, has been well characterized in this laboratory. It increases the binding of epidermal growth factor in a unique manner via its own receptor. In the first 20 N-terminal amino acids sequenced, EF showed 50% homology to human Group II phospholipase A2 (PLA2). Here we propose that EF is yet another, unidentif...

Tlhe role of ABO blood groups in differential susceptibility to various diseases lhas lonig been a subject of investigation ani(1 debate(1). The genetic factors involve(l in resistanice against Virus infectionis lhave been reviewed by Allison(2). In the l)ast few years tlhree reports l)y Englislh writers lhave claimed to slhow a hiiglher susceptibility of persons of )loo0( grotup 0 to influenza...

OBJECTIVE To investigate the frequency of metabolic syndrome and its components in subjects with β-thalassaemia minor. SUBJECTS AND METHODS A total of 194 subjects, i.e. 92 subjects with β-thalassaemia minor (study group) and 102 subjects without β-thalassaemia minor (control group), were enrolled into this case-control study. Haemoglobin electrophoresis was performed on all patients. The wai...

Halofantrine hydrochloride (halfan) was administered via oral route to matured female wistar rats weighing 180-200 g. The Wistar rats were randomly selected and divided into six groups of four rats each, making a total of twenty four rats and coded A1, A2, A3, B1, B2 and B3. Groups A3 and B3 were used as controls. Three consecutive doses of 1 mg/100 g halfan each were administered to group A1 a...

Background Adenosine is a purine nucleoside, which modifies different physiological functions, including vascular tone in numerous blood vessels. This effect is a consequence of interaction between adenosine and specific adenosine A1, A2 or A3 receptors. Still, the relaxant effect of this endogenous nucleoside has been shown on some blood vessels to be mainly dependent on activation of adenosin...

The link among blood pressure, sympathetic output, and brain neurons producing catecholamines is well documented. Nevertheless, their intrinsic properties and any alterations in signaling characteristics between normotensive and hypertensive phenotypes remain unknown. Here, we directly compared neurophysiological properties of catecholamine release of C1 and A2 neurons of the spontaneously hype...

Thromboxane A2 is a prostanoid having potent platelet aggregatory and vasoconstrictor properties. To determine a possible role for thromboxane A2 in the development of severe hypertension and stroke, we chronically administered the selective thromboxane A2 synthase inhibitor UK-38,485 (Dazmegrel) to stroke-prone spontaneously hypertensive rats (SHRSP). Serum thromboxane B2 (the stable hydrolysi...

BACKGROUND Melanocortin 1 Receptor (MC1R) is expressed in a majority of melanoma biopsies and cell lines. We previously demonstrated that three hydrophobic low-affinity HLA-A2-restricted MC1R-derived peptides: MC1R291-298, MC1R244-252 and MC1R283-291 can elicit cytotoxic T-lymphocytes (CTL) responses from normal donor peripheral blood lymphocytes (PBL). Moreover, peptide-specific CTL recognized...