Each family of signal transduction systems requires specificity determinants that link individual signals to the correct regulatory output. In Bacillus subtilis, a family of four anti-terminator proteins controls the expression of genes for the utilisation of alternative sugars. These regulatory systems contain the anti-terminator proteins and a RNA structure, the RNA anti-terminator (RAT) that...

A26-year-old black woman with a history of systemic lupus erythematosus (SLE) and hypertension presented to the Hermann Hospital emergency department with a 1-week history of retrosternal chest pain described as constant and sharp. She stated that the pain occurred at rest, increased with deep inspiration, was not related to position or meals, and lasted all day long, although she did note epis...

The Zika virus disease is an Aedes mosquito-borne disease caused by the ZIKA virus. The unavailability of vaccines or proper chemotherapeutic treatment emphasizes the need for the development of preventive and therapeutic vaccines. T cell specific epitopes have been used as vaccine candidates to generate desired immune responses against a variety of viral pathogens. Herein, the immune-informati...

To the Editor: 1 work at an overseas American institution, and there are extended delays in receipt of journals by our medical library. So, it was only a few days ago that I saw the article entitled “Weak Association between HLA-B27 and the Spondylarthropies in Lebanon,” which was published in the February 1997 issue of Arthritis & Rheumatism (1). I would like to draw the attention of the Leban...

The U.S. government routinely misstates interest costs on government debt. These misstatements occur partly because the government fails to account properly for the real capital losses government creditors experience during inflationary periods.1 In addition, the government imperfectly measures the fluctuations in returns to its creditors from changes in interest rates and the maturity composit...

The objective of this study was to analyse parameters in rhesus monkey collagen-induced arthritis (CIA) with which the inflammation and destruction of the joints can be described in quantitative terms. CIA was induced in genetically susceptible and resistant monkeys, which can be distinguished on the basis of the dominant resistance marker Mamu-A26. The disease course was monitored daily using ...

Refractory bone and soft tissue sarcomas are challenging diseases to treat because of their robustness to chemotherapy. Although cancer vaccines have the potential to become an attractive treatment modality, their progress has been hampered by the presence of many subtypes of sarcomas and different human leukocyte antigen (HLA)-types. We investigated whether personalized peptide vaccination (PP...

Type 1 diabetes (T1D) is a polygenic autoimmune disease. Susceptibility to T1D is strongly linked to a major genetic locus that is the major histocompatibility complex (MHC) and several other minor loci including insulin, CTLA4 that contribute to diabetes risk in an epistatic way. MHC harbours genes whose primary function is to govern immune responsiveness. Being the most polymorphic genomic re...