Human rhinoviruses (HRVs) frequently cause mild upper respiratory tract infections and more severe disease manifestations such as bronchiolitis and asthma exacerbations. HRV is classified into three species within the genus Enterovirus of the family Picornaviridae. HRV species A and B contain 75 and 25 serotypes identified by cross-neutralization assays, although the use of such assays for rout...

Epidemic methicillin-resistant Staphylococcus aureus 16 (EMRSA-16) and EMRSA-15 are the two most important and prevalent EMRSA strains found in the United Kingdom and have also been found in a number of European countries and the United States. We describe for the first time the spread of an EMRSA strain (EMRSA-16) from its point of origin in one hospital to the surrounding hospitals and region...

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The fundamental relationship between DNA sequence/deformability and biological function has attracted numerous experimental and theoretical studies. A classic prototype system used for such studies in eukaryotes is the complex between the TATA element transcriptional regulator and the TATA-box binding protein (TBP). The recent crystallographic study by Burley and co-workers demonstrated the rem...

Birdshot chorioretinopathy is a relatively uncommon subtype of idiopathic posterior uveitis with distinct clinical characteristics and a strong genetic association with the Human Leukocyte Antigen (HLA)-A29 allele. The diagnosis remains clinical and is based on the presence of typical clinical features, including multiple, distinctive, hypopigmented choroidal lesions throughout the fundus. The ...

Birdshot chorioretinitis (BSCR), an ocular autoimmune disease, is one of the most well-characterized posterior uveitis syndromes, with its strong HLA-A29 haplotype association and characteristic disease features (i.e., optic disc edema, periphlebitis, cystoid macular edema, and chorioretinal lesions leading to degenerative changes of the retina, choroid, and retinal pigment epithelium). The spe...

We use data from the Isaac Newton Telescope Wide Field Camera survey of M31 to determine the surface brightness profile of M31 along the south-east minor axis. We combine surface photometry and faint red giant branch star counts to trace the profile from the innermost regions out to a projected radius of 4 (≈ 55 kpc) where μV ∼ 32 mag arcsec ; this is the first time the M31 minor axis profile h...

We use data from the Isaac Newton Telescope Wide Field Camera survey of M31 to determine the surface brightness profile of M31 along the south-east minor axis. We combine surface photometry and faint red giant branch star counts to trace the profile from the innermost regions out to a projected radius of 4 (≈ 55 kpc) where μV ∼ 32 mag arcsec ; this is the first time the M31 minor axis profile h...

PURPOSE Because the expression of classic and nonclassic HLA antigens is crucial for the recognition and elimination of tumor cells by cytotoxic T and/or NK cells, we analyzed the HLA-A, -B, -C, and -G expression in uveal melanoma specimens from 18 patients. METHODS Tumor specimens and EDTA plasma samples from 18 patients treated by primary enucleation or tumor resection for primary uveal mel...