Aluminum, the most abundant neurotoxic metal in our biosphere, has been implicated in the etiology of several neurodegenerative disorders including Alzheimer's disease (AD). To further understand aluminum's influence on gene expression, we examined total messenger RNA levels in untransformed human neural cells exposed to 100 nanomolar aluminum sulfate using high density DNA microarrays that int...

Efforts to understand how plants respond to aluminum have focused on describing the symptoms of toxicity and elucidating mechanisms of tolerance; however, little is known about the signal transduction steps that initiate the plant's response. Here, we image cortical microtubules and quantify plasma-membrane potential in living, root cells of intact Arabidopsis seedlings. We show that aluminum d...

in recent years, a potential connection between human intake of aluminum and alzheimer’s disease has drawn attention to the aluminum concentration in drinking water. it is therefore of interest to investigate the aluminum concentration m drinking water, produced under different circumstances. a random selection of 152 water samples were taken by the supply source including ground, surface and a...

background: several adjuvants have been evaluated for vaccine formulations but alu-minum salts will continue to be used for many years due to their safety, low cost and adjuvanticity with different antigens. two commonly used aluminum adjuvants, alumi-num hydroxide and aluminum phosphate have different adjuvanticity properties. com-mercial recombinant protein hepatitis b vaccines containing alu...

We have studied the impact of dissolved aluminum on interfacial properties of two aluminum bearing minerals, corundum and kaolinite. The effect of intentionally adding dissolved aluminum on electrokinetic potential of basal plane surfaces of sapphire was studied by streaming potential measurements as a function of pH and was complemented by a second harmonic generation (SHG) study at pH 6. The ...

Zeolites are aluminosilicates that are used in many applications involving catalysis, separation, and gas storage. Unlike the Si/Al ratio of their framework, the location of the aluminum atoms is not well described. It has proved difficult to establish the local structure surrounding the aluminum sites by diffraction methods, since aluminum and silicon are very close in X-ray scattering power a...

The purpose of the present study was to investigate the in vitro and in vivo effects of aluminum sulfate on delta-aminolevulinic acid dehydratase (ALA-D) activity from the brain, liver and kidney of adult mice (Swiss albine). In vitro experiments showed that the aluminum sulfate concentration needed to inhibit the enzyme activity was 1.0-5.0 mM (N = 3) in brain, 4.0-5.0 mM (N = 3) in liver and ...

Aluminum is the most abundant metal in the Earth's crust and a highly sought after fuel source due to its extreme energy density. It has the ability to produce large quantities of hydrogen and heat when reacted with water making it an attractive fuel for underwater vehicles and ocean sensor platforms. The biggest challenge in using aluminum as a fuel has been overcoming the rapidly-forming oxid...

Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially in children who receive a vaccination series starting at birth. The pharmacokinetic properties and end-point toxicities of aluminum are presented. In assessing the relevance of dietary and medical aluminum exposure t...

Increasing use of aluminum shape castings in automotive and aerospace industries has drawn great attention to fatigue properties of cast aluminum components. The fatigue resistance of aluminum castings strongly depends upon the presence of casting flaws and characteristics of microstructural constituents. The existence of casting flaws significantly reduces fatigue crack initiation life. In the...