A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reversible "on/off" fluorescence in response to cellular pH variations. Using this system, the high-throughput quantification between surface-bound and internalized capsules is demonstrated. This system allows a fundamental study of the interaction between nanoengineered...

High efficient loading and controlled release of low-molecular-weight drugs were achieved facilely by heat-shrinkage of polyelectrolyte multilayer capsules with a spontaneous deposition property. The capsules consisting of 5 bilayers of poly(diallyldimethylammonium chloride) and poly(styrene sulfonate) (PSS) were assembled on PSS-doped CaCO3 particles. After core removal, a part of PSS molecule...

Novel "micelles enhanced" polyelectrolyte (PE) capsules based on functional templates of hybrid calcium carbonate were fabricated. Evidences suggested that the structure of capsule wall was different from that of conventional PE capsules, and the wall permeability of these PE capsules changed significantly. Lysozyme, a positively charged protein in neutral solution, was studied as a model prote...

Polyelectrolyte multilayer sensor capsules, 5 microm in diameter, which contained fluorescein-labeled poly(acrylic acid) (PAAAF) as pH-sensitive reporter molecules, were fabricated and employed to explore their endocytotic uptake into HEK 293T cells by flow cytometry. The percentage of capsules residing in the endolysosomal compartment was estimated from the fluorescence intensity decrease caus...

Buildings are the major energy users and by 2035, they will be fourth largest source of greenhouse gas emissions. Phase change materials (PCMs) applied to shift peak-load off-peak-load, positively effecting efficiency building. In this paper, an experimental embedding PCM (Paraffin) with bricks in conventional wall layers is carried out. The effect on thermal diffusion inner surface studied. Ca...

Between January 1, 2015, and the end of October, there were >6,500 peer-reviewed papers listed in PubMed on asthma. Of necessity, those that have been selected for inclusion for this Year in Review represent a few that have caught the reviewer's interest, organized by themes. Not unexpectedly, some of these papers are in conflict with each other, whereas others raise more questions then they ap...

Over the last decade versatile, electrostatic layer-by-layer (LbL) assembly methods involving polyelectrolytes have been widely used in the preparation of hollow capsules. These capsules can be fabricated by the stepwise adsorption of polyelectrolytes with charges that are opposite from their aqueous media onto templating cores, especially organic or inorganic particles and biopolymers, followe...

Überblick. Mit Hilfe von Funktionsbausteinadaptern (FBAs) kann die Kommunikation zwischen Funktionsbausteinen der IEC 61131-3 und Capsules der Unified Modeling Language (UML) in einer formalen Sprache spezifiziert werden. Diese Spezifikation wird während der Entwurfsphase eines Systemes erstellt und ist hardware-unabhängig. Nachrichten, die von Capsules an Funktionsbausteine geschickt werden so...

A condenação de vísceras bovinas ainda é comum nos frigoríficos brasileiros e está entre as principais causas perdas. produção boa qualidade depende, outros fatores, das técnicas adotadas na fazenda no frigorifico, pré-abate abate. identificação importante, pois, fornece suporte para melhorias processo produtivo, auxiliando redução O presente estudo teve por objetivo identificar avaliar frequên...