Topical ethanol is used as a dermal penetration enhancer in some commercial products. Previous studies have demonstrated that chronic ethanol consumption can also disrupt skin barrier function, leading to increased transdermal penetration. This observation becomes much more relevant if a single drinking episode induces similar changes. The purpose of this study was thus to examine the transderm...

The enhancer element of hepatitis B virus (HBV) regulates the transcription of all HBV mRNA, including the pregenomic mRNA used during replication. This pregenomic mRNA is transcribed from the core gene promoter which is located 500 bp downstream from the HBV enhancer element. To examine the effect of the HBV enhancer on the activity of the core gene promoter, we constructed various plasmids co...

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...

The shadow enhancer of the short gastrulation (sog) gene directs its sequential expression in the neurogenic ectoderm and the ventral midline of the developing Drosophila embryo. Here, we characterize three unusual features of the shadow enhancer midline activity. First, the minimal regions for the two different enhancer activities exhibit high overlap within the shadow enhancer, meaning that o...

We recently found that a polypeptide, the C-terminal of Clostridium perfringens enterotoxin (C-CPE), was a novel type of drug absorption enhancer. The C-terminal of C-CPE is thought to play a role in the binding of C-CPE to its receptor, claudin-4; however, the function of the N-terminal of C-CPE is unclear. In the present study, we evaluated the role of the N-terminal domain of C-CPE in jejuna...

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan derivatives have been studied as permeation enhancer in free soluble form and as nanoparticulate systems. The aim of the current work wa...

Across the Global South, post-consumer waste glass is an often dumped, and under-utilised resource. Even in Malawi, with widespread return schemes, many barriers exist, inhibiting reuse, necessitating appropriate solutions. The purpose of this article to evaluate performance as a coarse aggregate within burnt clay bricks, assess feasibility for recovery material from dumped stocks Chembe. Using...

Phytogenic feed additives are used as antibacterial, anti-inflammatory and performance enhancer in the nutrition of broiler chicks. In present study, it was aimed to investigate effects usage phytogenic which an alternative antibiotics broilers at different levels rations, on morphology duodenum ileum. For this purpose, 48 male ROSS-308 one-day-old chicks were study. Chicks with a body weight 4...

Infiltrating phase change materials (PCMs) into nanoporous metal–organic frameworks (MOFs) is accepted as a cutting-edge thermal energy storage concept. However, weak photon capture capability of pristine MOF-based composite PCMs stumbling block in solar utilization. Towards this goal, we prepared advanced high-performance photothermal by simultaneously integrating absorber guest (polypyrrole [...