Warty dyskeratoma (WD) is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middle-aged or older persons. Histologically, it shows a cup-shaped keratin-filled invagination of an acanthotic epidermis, suprabasilar clefting with villi projecting into the clefts and acantholytic dyskeratotic cells are also present. The changes almost always involve a single...

A 45 year old man presented with abdominal pain, loss of appetite, and significant weight loss over a period of about four weeks. Imaging of the abdomen showed a mass in the region of the head of the pancreas. In view of the size of the mass and the clinical picture, a Whipple's procedure was performed. Histological evaluation of the pancreatic tumour showed an adenosquamous carcinoma (predomin...

A) Verruca vulgaris B) Actinic keratosis C) Bowenoid papulosis D) Seborrheic keratosis E) Acanthoma High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). Citation: Kupetsky EA, Charles CA, Mones J. High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). A case and review. Copyright: ©2015 Kupetsky et al. This is an open-access ar...

Fig 1. Papular acantholytic dyskeratosis. Red-pink verrucous papules in a linear distribution. CASE REPORT A 78-year-old man was hospitalized for resection of a craniopharyngioma. His postoperative course was complicated by infections and a 4-month-long hospitalization. The dermatology department was consulted because of a new inguinal rash. The patient noted a 7-day history of a nonpruritic, n...

BACKGROUND acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction. METHODS Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous s...

BACKGROUND The microscopic and microbial features of the spreading epidermal collarettes of canine exfoliative superficial pyodermas are poorly characterized. OBJECTIVES To characterize the clinical, cytological, microbial and histopathological features of epidermal collarettes in five dogs. RESULTS Cytology from the margins of collarettes identified neutrophils, extracellular and intracell...

Keratinocyte differentiation, adhesion and motility are directed by extracellular Ca2+ concentration increases, which in turn increase intracellular Ca2+ levels. Normal keratinocytes, in contrast to most non-excitable cells, require Ca2+ release from both Golgi and endoplasmic reticulum Ca2+ stores for efficient Ca2+ signaling. Dysfunction of the Golgi human secretory pathway Ca2+-ATPase hSPCA1...