fundamental observations about cardiac pathophysiology. The purpose of this editorial comment is to expand the findings covered in that review to demonstrate how clinical investigators have applied those advances in electrocardiography toward an understanding of the physiology of cardiac arrhythmias (2–4). This knowledge has enabled the practicing cardiologist, armed with no more than a pair of...

Mahaim fibres are cardiac accessory bundles which can cause dangerous tachyarrhythmias. Despite their first description being many years ago, their recognition and diagnosis still proves difficult. The electrocardiographic features of Mahaim pathways are subtle and shared with other accessory pathways; as such, an electrophysiology study must be used to diagnose this pathway. Even then, it is o...

To position the mitotic spindle, cytoskeletal components must be coordinated to generate cortical forces on astral microtubules. Although the dynein motor is common to many spindle orientation systems, 'accessory pathways' are often also required. In this work, we identified an accessory spindle orientation pathway in Drosophila that functions with Dynein during planar cell polarity, downstream...

Background: This study assessed the efficacy and safety of techniques used to ablate left-sided accessory atrioventricular pathways at atrial insertion sites by retrograde aortic approach. Radiofrequency catheter ablation of left-sided accessory pathways by way of retrograde aortic approach can be highly successful. Methods: This study were done in the department of Cardiology, National Institu...