BACKGROUND Radiofrequency ablation (RFA) for atrioventricular nodal reentrant tachycardia appears to reduce atrial tachycardia, which might relate to parasympathetic denervation at cardiac ganglionated plexuses. METHODS AND RESULTS Compared to 7 control canines without RFA, in 14 canines, RFA at the bottom of Koch's triangle attenuated vagal stimulation-induced effective refractory periods pr...

A case of permanent unintentional ablation of an accessory pathway during electrophysiological study is reported. Possible factors predisposing to such ablation include the location and depth below the endocardium of the accessory pathway.

BACKGROUND The direction of impulse propagation across the coronary sinus (CS) musculature (CSM) is an important piece of the mechanistic puzzle underlying atrial tachyarrhythmias. We hypothesized that in the general population, the sequence of left atrial (LA) to CSM electrograms recorded in the CS reflects the direction of impulse propagation over the CSM. METHODS We studied 19 patients wit...

The appearance of syncope in a patient with an accessory pathway is often a sign of high conduction capacity along the pathway, and calls for urgent ablation. Serious complications may ensue if it is assumed that these patients have an underlying mechanism of tachyarrhythmia, and ablation of the accessory pathway performed hastily without careful electrophysiological evaluation may lead to seri...

pathway and subtle preexcitation, the AH intervals were short. These data pertain to a predominantly adult population. Only 1 of the patients was <12 years old. This patient showed a minimal preexcitation pattern and the pathway was in the left lateral region. These data cannot be extrapolated to the pediatric population, in general, who may have relatively shorter atrioventricular nodal conduc...

The anatomic location of atrioventricular (AV) bypass tracts (or accessory pathways) is variable, but these generally traverse the tricuspid or mitral annulus and insert into the atrium and ventricle near the AV ring. There is only 1 case report of an accessory pathway ablated in the left coronary cusp (LCC), and this pathway had bidirectional conduction, was not decremental, and was associated...

background: acute promyelocytic leukemia (apl) is a unique subtype of acute leukemia. apl is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in apl patient management. one issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. materials and methods: in ...

BACKGROUND Septal accessory atrioventricular (AV) pathways may be located in close vicinity of the His bundle-AV nodal conduction system. Attempts at surgical or electrical interruption of these pathways may therefore result in impairment of normal AV conduction. This study focuses on a subset of septal pathways with an atrial insertion located inside the triangle of Koch. In this study, they w...