This paper is concerned with the dependence structure of a multi-component, cumulative damage shock model, in which a system of components is subject to correlated shock damages and group repairs. A component fails when its cumulative damage exceeds a given threshold, and is then replaced by a new component. We incorporate a block maintenance schedule that simultaneously performs imperfect repa...

On the basis of plastic bounding surface model, the damage theory for structured soils and unsaturated soil mechanics, an elastoplastic model for unsaturated loessic soils under cyclic loading has been elaborated. Firstly, the description of bond degradation in a damage framework is given, linking the damage of soil’s structure to the accumulated strain. The Barcelona Basic Model (BBM) was cons...

Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While tumor cells utilize autophagy to survive metabolic stress, autophagy also mitigates the resulting cellular damage that may limit tumorigenesis. In response to stress, autophagy-defective tumor cells preferentially accumulated...

Value-based decisions are biased by the time people spend viewing each option: Options fixated longer are chosen more often, even when previously rated as less appealing. This bias is thought to reflect 'value updating' as new evidence is accumulated. Prior work has shown that ventromedial prefrontal cortex (PFC) carries a fixation-dependent value comparison signal, while other studies implicat...

Two efficient methods for time-dependent fatigue reliability analysis are proposed in this paper based on a random process representation of material fatigue properties and a nonlinear damage accumulation rule. The first method is developed by matching the first two central moments of the accumulated damage to a well-known probability distribution, thus facilitating direct analytical solution o...

Ribonucleases H (RNases H) are endonucleases which cleave the RNA moiety of RNA/DNA hybrids. Their function in mammalian cells is incompletely understood. RNase H2 mutations cause Aicardi-Goutières syndrome, an inflammatory condition clinically overlapping with lupus erythematosus. We show that RNase H2 is essential in mouse embryonic development. RNase H2-deficient cells proliferated slower th...

In this issue of the Journal, McGraw et al. ([2006] Am. J. Phys. Anthropol. 000:00-00) present new data on the taphonomic signature of bone assemblages accumulated by crowned hawk eagles (Stephanoaetus coronatus), including characteristic talon damage to the inferior orbits of primates preyed upon by these birds. Reexamination of the Taung juvenile hominin specimen (the type specimen of Austral...

Synchronized human lymphoma cells treated with bleomycin exhibited the greatest sensitivity in G2. Doseresponse curves presented biphasic characteristics indicating the presence of sensitive and less sensitive cells in all stages of the cell cycle. Synchronized cells incubated with 1,3bis(2-chloroethyl)-l-nitrosourea also showed the greatest sensitivity in G2A threshold-type dose-response survi...