The angiotensin I-converting enzyme (ACE) converts the inactive angiotensin I molecule to the active angiotensin II. ACE is rich in epithelium, endothelium, and neuroepithelial cells and it found largely on the brush border of intestine and kidney proximal tubules. ACE also presents in the serum. Some pulmonary and renal toxic drugs change the serum and tissue ACE contents. In this research ACE...

OBJECTIVE This study determined the role of angiotensin-converting enzyme (ACE) on the development of angiotensin I-induced atherosclerosis and the contribution of leukocyte-specific expression of this enzyme. APPROACH AND RESULTS To define the contribution of ACE-dependent activity to angiotensin II synthesis in atherosclerotic development, male low-density lipoprotein receptor(-/-) mice wer...

Lizard fish (Saurida elongata) muscle protein was hydrolyzed using neutral protease to produce protein hydrolysate (LFPH), and the hydrolysis conditions were investigated using response-surface methodology. The optimum conditions for producing peptides with the highest angiotensin-I converting enzyme (ACE)-inhibitory activity were the following: enzyme-to-substrate ratio of 10,000 U/g, temperat...

The phosphorylation of the short C-terminal cytoplasmic domain of the somatic angiotensin-converting enzyme (ACE) is involved in the regulation of enzyme shedding. We determined whether the phosphorylation of the cytoplasmic domain of ACE (ACEct) on Ser1270 regulates the cleavage/secretion of the enzyme by affecting its association with other proteins. ACE was associated with beta-actin and the...

Pulmonary fibrosis is a progressive disorder characterized by the loss of alveolar architecture through epithelial and endothelial cell apoptosis and fibroblast proliferation. Recent studies showed that angiotensin-converting enzyme (ACE) activity is increased in fibrotic tissues, and ACE inhibitors administered in vivo ameliorate fibrosis, suggesting that ACE may play a critical role. However,...

Abstract This research examined the variation in concentration of protein derived from jack bean throughout mold fermentation and distribution molecular weight (MW) resultant peptides. In addition, effects peptide size on ACE inhibitory action were investigated. The was soaked boiled before fermentation, then inoculated using 0.2% commercial tempe inoculum. Furthermore, seeds incubated at room ...

this study was conducted to determine the effects of administration of different concentration of aloe vera crud extract (ace) as a food supplement on growth performance, immune response and disease resistance against aeromonas hydrophila (chester) infection in cyprinus carpio. 360 juvenile c.carpio were randomly divided into four equal groups in triplicates. groups 1 to 4 were fed by basal foo...

PURPOSE Aronia crude extract (ACE) with high levels of polyphenol compounds has been reported to have antioxidative effects in vitro and in vivo. In this study, attention was focused on the antioxidant effect of ACE. The purpose of the present study was to investigate the effect of ACE on endotoxin-induced uveitis (EIU) in rats. In addition, the endotoxin-induced expression of the inducible nit...

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency ...

Hypertension is a significant public health problem worldwide, leading risk factor for cardiovascular disease and cause of premature death. Angiotensin-I-converting enzyme (ACE) activity one the causes hypertension. Lamtoro Gung has potential as an Enzyme Inhibitory (ACE-I) due to presence peptide that able inhibit its prevent The germination process was carried out hydrolyse storage proteins p...