The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent evaporation and kneading techniques. The solid dis...

The aim of this study was to examine correlation between anti-inflammatory activity and molecular properties of the ten selected natural products in search of a lead compound through Molinspiration, Osiris and PASS cheminformatics software. Ten naturally occurring natural products of diverse chemical classes which seem to be promising and potential candidate for the drug development or identifi...

OBJECTIVES A prospective, multicenter, randomized, double-blind, placebo-controlled trial evaluated the effects of naftopidil 75 mg for medical expulsive therapy for a single ureter stone. MATERIALS AND METHODS Patients diagnosed with a ureter stone were prescribed aceclofenac 100 mg or a combined medication of tramadol 37.5 mg and acetaminophen 325 mg. Patients then randomly received either ...

The objective of the present investigation was to design suitable Immediate release tablet formulation of Aceclofenac by using cross carmellose sodium as super-disintegrant in four different concentrations i.e., 0, 4, 6, 8% w/w of tablet weight by two granulation methods i.e., Wet and melt granulation methods. The objective of the research was to compare the two granulation methods i.e., wet an...

Arthritis is a major cause of disability and morbidity, particularly in older individuals. The symptoms and signs of arthritis and related conditions include pain, stiffness, swelling, muscle weakness, and limitation of movement of the joints. The objective of the present work was to provide a dosage form for localized action of drugs used in treatment of arthritis to the affected tissues for p...

In this study five marketed brands of aceclofenac 100 mg tablets have been evaluated using dissolution test in two different media with the aim to assess bioequivalence and to select a proper dissolution medium. Other general quality parameters of these tablets like weight variation, hardness, friability, disintegration time were also determined according to established protocols. All the brand...

The aim of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal antiinflammatory drugs (NSAIDs) agents having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology,(SEM) scanning electronic microscopy, vesic...

The present investigation reports the various pharmacokinetic parameters of immediate release aceclofenac tablets incorporating its inclusion complex with hydroxypropyl-β-cyclodextrin. The tablets were prepared using aceclofenac: hydroxypropyl-β-cyclodextrin in a 1:1 molar ratio by the direct compression method (TKN). The results were compared with those of the marketed brand (MKT) and pure dru...