pharmacological activities of 6-(4-hydroxy-3-methoxyphenyl)-hexanonic acid (hmpha), a phenolic compound, isolated from the extract of pycnocycla spinosa was investigated on ileum motility in vivo and in vitro . ileum motility was examined by measuring charcoal movement through the gut in mice. in addition, antidiarrhoeal activity of hmpha was assessed and compared with standard drug; loperamide...

rosa damascena flower is widely used for gastrointestinal (gi) disorders. however, its pharmacological action on isolated ileum has not been studied. in this research, the effect of extract of flower petals of r. damascena mill. growing in kashan, iran, on ileum motility was investigated. hydroalcoholic extract was prepared by percolation method. a section of rat ileum was suspended in an organ...

Experiments were designed to test the hypothesis that nicotinic acetylcholine receptors (nAChRs) are present at sites of neurotransmission to the guinea pig ileum circular smooth muscle. Circular smooth muscle preparations, from which the myenteric plexus had been removed (circular muscle-axon preparation), were used for this purpose. Nicotine and dimethylphenyl piperazinium iodide (10-100 micr...

zataria multiflora boiss. is used in iranian traditional medicine to treat gastrointestinal disorders and menrrhalgia. the inhibitory effect of this herb on rat ileum contractions is also reported. the aim of this study was to investigate the effect of zataria multiflora boiss. hydroalcoholic leaf extract (zhle) on isolated rat uterus in presence of some known uterus stimulants. pieces of virgi...

Neuromuscular transmission at the skeletal muscle occurs when a quantum of acetylcholine from the nerve ending is released and binds to the nicotinic acetylcholine receptors on the postjunctional muscle membrane. The nicotinic acetylcholine receptors on the endplate respond by opening channels for the influx of sodium ions and subsequent endplate depolarisation leads to muscle contraction. The ...

Introduction: Dill (Anethum graveolens), a herb from from Umbelliferae, is used traditionally to treat convulsion and increasing milk production. Its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. The spasmolytic effect of dill fruit on rat uterus has also been shown recently. The aim of present study was to i...

hydroalcoholic extract of pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. as p. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. therefore, the aim of this study was to determine the effect of p. spinosa extract on rat bladder contraction. in an in vitro study, the effects of p. spinosa extract, nifedipine an...

seeds of moringa peregrina (forssk.) fiori. (moringaceae) is widely used in south east of iran for gastrointestinal disorders. however, so far there is no pharmacological evidence for antispasmodic activity of this plant extract. therefore, the aim of this research was to investigate antispasmodic activity of m. peregrina on rat isolated ileum contraction. hydroalcoholic extract was obtained by...

Background and Aims: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of silymarin. In this study the effect of chronic administration of silymarin on contractile-relaxation response of thoracic aorta of diabetic rats was investigated. Methods: In this experimental study, male Wistar rats were divided into 5 gro...

The contraction of intestinal smooth muscle cells (ISMCs) is a complex process, involving many chemical reactions and mechanical triggers working to produce the contraction-relaxation cycle. Due to its complexity, it is difficult to isolate the effect of one factor on the overall process. Mathematical modeling allows one to test various combinations of parameters and structural geometries to as...