Marchantia polymorpha L. is a representative bryophyte used as a traditional Chinese medicinal herb for scald and pneumonia. The phytochemicals in M. polymorpha L. are terpenoids and flavonoids, among which especially the flavonoids show significant human health benefits. Many researches on the gametophyte of M. polymorpha L. have been reported. However, as the reproductive organ of M. polymorp...

acetylcholinesterase (ache) is the main enzyme for the breakdown of acetylcholine. nowadays, usage of the inhibitors of this enzyme is one of the most important types of treatment of mild to moderate neurodegenerative diseases such as alzheimer’s disease. herbal medicines can be a new source of inhibitors of this enzyme. in this study we examined around 100 different plants to evaluate their in...

Newly arisen adaptive alleles such as insecticide resistance genes represent a good opportunity to investigate the theories put forth to explain the molecular basis of dominance and its possible evolution. Dominance levels of insecticide resistance conferred by insensitive alleles of the acetylcholinesterase gene were analyzed in five resistant strains of the mosquito Culex pipiens. Dominance l...

BACKGROUND Pharmacological treatment of orthostatic hypotension is often limited because of troublesome supine hypertension. OBJECTIVE To investigate a novel approach to treatment using acetylcholinesterase inhibition, based on the theory that enhanced sympathetic ganglion transmission increases systemic resistance in proportion to orthostatic needs. DESIGN Prospective open label single dos...

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data used to determine structure compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability inhibit acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) en...

Alzheimer's Disease (AD), one of the diseases that still has no a specific therapy, become major public health issue owing to increasing population elderly, particularly in rich countries. Inhibitory cholinesterase enzymes (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which hydrolyze acetylcholine (ACh) butyrylcholine (BCh) neurotransmitters, have recently choice for therapy th...

Many organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. The methods used in the literature to determine the inhibition kinetic constants usually involve either manual determination of the slope at various points along the inhibition progress curve or fitting polynomials to the curve. The present study investigates the use of non-linear-regression analysis to determi...

Chlorpyrifos is a commonly used insecticide that can be metabolically activated by CYP2B to the acetylcholinesterase inhibitor chlorpyrifos-oxon causing cholinergic overstimulation and neurotoxicity. Rat brain extracts can also activate chlorpyrifos in vitro, and the lack of circulating oxon in serum suggests that metabolic activation within the brain may be responsible for chlorpyrifos neuroto...

Objectives: The objective of present study is to determine the efficacy ethanolic extract Evolvulus alsinoides Linn. for therapeutics at various doses. One more purpose also anti-inflammatory effects E. which are highly associated with CNS disease. Methods: Ethanolic has been used estimation acetylcholinesterase inhibitory activity dose 100, 200, 300 mg/kg on rat. For acetylcholinesterase, Ellm...