Galactokinase plays a key role in normal galactose metabolism by catalyzing the conversion of alpha-d-galactose to galactose 1-phosphate. Within recent years, the three-dimensional structures of human galactokinase and two bacterial forms of the enzyme have been determined. Originally, the gene encoding galactokinase in humans was mapped to chromosome 17. An additional gene, encoding a protein ...

Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality also useful chemical tool selectively depleting various targets. As most efforts focus on cytosolic proteins using PROteolysis TArgeting Chimera (PROTAC), LYsosome (LYTAC) recently emerged promising to deliver extracell...

Pasteurella multocida subsp. is responsible for different diseases that generate great economic losses in farm animal. The effectiveness of immunization against those bacteria are variable and the use antibiotics questioned; reason, we investigated potential inhibitory effect carbohydrates on adherence vivo P. to rabbit respiratory epithelium as an alternative prevention infections. Rabbits wer...