A series of novel N'-((5-nitrofuran-2-yl/4-nitrophenyl) methylene) substituted hydrazides (3a-3i & 4a-4i) was synthesized, and tested for in vitro antimycobacterial activity, and their quantitative structure activity relationship (QSAR) of hydrazide derivatives is reported here. The results of anti-mycobacterial activity study indicated that the presence of halogen substitution at benzohydrazid...

E SR has been used in the study of iron(I)-nitrosyl complexes w ith organic ligands in solution. Four types of complexes have been identified on basis of the ESR param eters, namely Fe (NO) L 5, Fe (NO) L 2, Fe (NO)2L 2, and Fe (NO)2L. In the iron-nitrosyl complexes with the organic ligands used, the groups more often involved in the coordination are: —C —N H 2; —C —N H ; — C = 0 ; and —C = S (...

Using the chick embryo assay system, a series of organic compounds was tested for lathyrogenic activity; lathyrogenic compounds were shown to fall into 4 groups-nitriles, ureides, and 2 new groups-hydrazides and hydrazines, forming a spectrum of diminishing potency in their ability to produce solubility of collagen and skeletal deformities. Pyridoxal was seen to reverse to a great degree the ef...

line therapeutic agents for the treatment of arthritis. NSAID’s reduce the pain and swelling associated with arthritis by blocking the metabolism of arachidonic acid (AA) through the enzyme cyclooxygenase (COX) and thereby the production of prostaglandins, e.g. PGE2, which sensitizes nociceptors at nerve fiber terminals. Additionally, the 5-lipoxygenase (5-LO) products such as leukotriene B4 (L...

A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides. Under the optimized reaction conditions, the reaction well tolerates a wide variety of functional groups to afford structurally diverse 2-arylindoles in good to excellent yields at 70 °C.

A series of twelve novel hybrids cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via chlorides, evaluated for their impact against Mycobacterium tuberculosis (Mtb) cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % all three treated Mtb isolates, whereas isoniaz...

3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good ...