Nisin is a positively charged antibacterial peptide which binds to the negatively charged membranes of Gram-positive bacteria. The initial interaction of the peptide with model membranes of neutral (phosphatidylcholine) and negatively charged (phosphatidylcholine/phosphatidylglycerol) model lipid membranes was studied using nonperturbing solid state magic angle spinning (MAS) (31)P NMR and (2)H...

Aim: The aim of this study was to compare the effect of an acidic and alkaline environment on the compressive strength of Grey Pro Root Mineral Trioxide Aggregate and Biodentine. Methodology: A total of eightyhuman, mandibular molars were used. Perforations were made in the furcation of each molar and enlarged to #3 Pesso drills. The repair was performed, according to the materials used. Sample...

objective: orthodontic wires should have high resistance against corrosion in the oral environment. since the effect of ph on corrosion has been well recognized, this study sought to assess and compare the electrochemical corrosion of orthodontic brackets and wires of different brands in acidic artificial saliva.   methods: this in vitro experimental study was conducted on 24 mandibular central...

The 2H2 monoclonal antibody recognizes the precursor peptide on immature dengue virus and might therefore be a useful tool for investigating the conformational change that occurs when the immature virus enters an acidic environment. During dengue virus maturation, spiky, immature, noninfectious virions change their structure to form smooth-surfaced particles in the slightly acidic environment o...

The present study is an attempt to find out the effect of environmental corrosion on the commonly used pearlitic rail steel. The cases of corrosion of rail under Indian environment have been studied. It has been found that in marine environment both the yield strength and tensile strength decreases with increasing corrosion rate. In acidic environment yield strength increased with increasing co...

The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic conditions by producing urease, which catalyzes hydrolysis of urea to yield ammonia thus elevating the pH of its environment. However, the manner in which H. pylori is able to swim through the viscoelastic mucus gel that c...

Lysosomotropic amines, such as ammonium chloride, are known to protect cells from the cytotoxic effects of diphtheria toxin. These drugs are believed to inhibit the transport of the toxin from a receptor at the cell exterior into the cytoplasm where a fragment of the toxin arrests protein synthesis. We studied the effects of lysosomotropic agents on the cytotoxic process to better understand ho...

Hypoxanthine is a mutagenic purine base that most commonly arises from the oxidative deamination of adenine. Damaged bases such as hypoxanthine are associated with carcinogenesis and cell death. This inevitable damage is counteracted by glycosylase enzymes, which cleave damaged bases from DNA. Alkyladenine DNA glycosylase (AAG) is the enzyme responsible for excising hypoxanthine from DNA in hum...