BACKGROUND Interleukin-17A is the signature cytokine of the Th17 subset and drives inflammatory pathology, but its relevance to autoantibody-mediated diseases is unclear. Th1 cells secreting interferon-γ have been implicated in autoimmune hemolytic anemia, so the aim was to determine which cytokine is more closely associated with disease severity. DESIGN AND METHODS Interferon-γ and interleuk...

W HEN THRICE-WASHED RED CELLS are agglutinated by rabbit anti-human-globulin sera (Coombs’ reagent), they are said to be “coated” with an “incomplete” (blocking) antibody.1 Such coating occurs in vivo in erythroblastosis fetalis as a result of placental transfer of maternal isoantibody, and in acquired hemolytic anemia of the immunologic variety2 (“autoimmune” hemolytic disease ) as a result of...

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by the triad of sudden onset hemolytic anemia, thrombocytopenia, and acute kidney injury. We describe rare case atypical HUS secondary to pancreatitis with an unknown etiology in 20-year-old male who presented complaint nausea, vomiting, abdominal pain.

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

Successful Treatment of Refractory Autoimmune Hemolytic Anemia (AIHA) in a Child, Based on Iranian Traditional Medicine: A Case Report

OBJECTIVES To present a case of acute brucellosis triggering acute hemolytic anemia in a subject with glucose-6-phosphate dehydrogenase (G6PD) deficiency. CLINICAL PRESENTATION AND INTERVENTION A 17-year-old male patient presented with fever, malaise and jaundice. His blood and bone marrow cultures yielded Brucella species. In addition, he was found to have acute hemolytic anemia due to previ...

Autoimmune hemolytic anemia (AIHA) has been described in patients with lymphoid neoplasm with an etiologic relationship between the emergence of autoantibodies and lymphocyte dysfunction. Autoimmune disorders are less to develop in patients with other neoplasm like chronic myeloid leukemia, myelodysplastic syndrome or acute myeloid leukemia. Few reports have been documented the development of i...

BACKGROUND Immune hemolytic anemia is a well-known complication after allogeneic hematopoietic stem cell transplantation (HSCT). Posttransplant hemolytic anemia results in increased red blood cell transfusions and medical sequelae including iron overload. CASE REPORT We present a case report of immune hemolytic anemia that occurred after allogeneic HSCT from an ABO major-mismatched, HLA-match...