نتایج جستجو برای: acting element

تعداد نتایج: 277184  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
J D Brenton R A Drewell S Viville K J Hilton S C Barton J F Ainscough M A Surani

The H19 gene is subject to genomic imprinting because it is methylated and repressed after paternal inheritance and is unmethylated and expressed after maternal inheritance. We recently identified a 1.1-kb control element in the upstream region of the H19 gene that functions as a cis-acting silencer element in Drosophila. Here we investigate the function of this element in mice. We demonstrate ...

Journal: :Journal of virology 1991
K R Steffy J P Weir

To investigate the cis-acting sequence elements that are involved in the regulation of herpes simplex virus type 1 late gene expression, linker-scanning mutations were constructed in the promoters of the glycoprotein C and glycoprotein H genes. Each promoter mutation was inserted upstream of the Escherichia coli lacZ gene in a recombinant virus, and the relative activities of beta-galactosidase...

Journal: :The Journal of biological chemistry 2007
Dorotea Rigamonti Daniele Bolognini Cesare Mutti Chiara Zuccato Marzia Tartari Francesco Sola Marta Valenza Aleksey G Kazantsev Elena Cattaneo

Increased levels of the repressor element 1/neuron restrictive silencer element (RE1/NRSE) silencing activity promoter, and a consequent reduction in the transcription of many RE1/NRSE-bearing neuronal genes, including brain-derived neurotrophic factor (BDNF), have been demonstrated in Huntington disease (HD) and represent one possible effector of its selective neuronal vulnerability. Restoring...

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