action potential propagation

Gap junctions provide a low-resistance pathway for cardiac electric propagation. The role of GJ regulation in arrhythmia is unclear, partly because of limited availability of pharmacological tools. Recently, we showed that a peptide called "RXP-E" binds to the carboxyl terminal of connexin43 and prevents chemically induced uncoupling in connexin43-expressing N2a cells. Here, pull-down experimen...

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the effects of two isolated fractions from buthotusschach scorpion venom on action potential properties in snail neurons

Journal: :پژوهش در پزشکی 0

هانیه تمدن hanieh tamadon neurophysiology research center and department of physiology, faculty of medicine, shahid beheshti university of medical sciences, tehran, iranمرکز تحقیقات نوروفیزیولوژی و گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی زهرا قاسمی zahra ghasemi neurophysiology research center and department of physiology, faculty of medicine, shahid beheshti university of medical sciences, tehran, iranمرکز تحقیقات نوروفیزیولوژی و گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی حسین وطن پور hossein vatanpour department of toxicology and pharmacology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iranگروه سم شناسی و داروسازی، دانشکده داروسازی، دانشگاه علوم پزشکی شهید بهشتی مهیار جان احمدی mahyar janahmadi neurophysiology research center and department of physiology, faculty of medicine, shahid beheshti university of medical sciences, tehran, iranمرکز تحقیقات نوروفیزیولوژی و گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی

abstract background: understanding the electrophysiological effects of toxins, may facilitate new drugs discovery. buthotusschach (bs) has been shown to be one of the most dangerous scorpions in tropical part of iran. present study was aimed to investigate the electrophysiological effects of two active fractions (f4 and f6) isolated from bs scorpion toxin on action potential (ap) characteristic...

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A model preconditioner for the Bidomain problem in electrocardiology

2008

M. Perego A. Veneziani L. Gerardo-Giorda L. Mirabella F. Nobile

We introduce a preconditioner for the solution of the Bidomain system governing the propagation of action potentials in the myocardial tissue, represented by a degenerate parabolic set of nonlinear reaction-diffusion equations. The nonlinear term describes the ion flux at the cellular level. The degenerate nature of the problem results in a severe ill conditioning of its discretization. Our pre...

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