Homeopathic preparations are used in homeopathy and anthroposophic medicine. Although there is evidence of effectiveness in several clinical studies, including double-blinded randomized controlled trials, their nature and mode of action could not be explained with current scientific approaches yet. Several physical methods have already been applied to investigate homeopathic preparations but it...

OBJECTIVE Transmural heterogeneity in the ventricular free wall, enhanced by the midmyocardial long action potential duration (APD) of M cells, plays an important role in the arrhythmogenesis of long QT syndrome. Although we observed dynamic expression of M cell phenotypes in the canine ventricular free wall, it is still unclear whether similar phenomena are present in the interventricular sept...

It has been established that some nonsteroidal anti-inflammatory drugs (NSAIDs) when administered through injectable preparations have a local irritating effect, even though the are considered high-quality. seems this irritant action is not related to any specific pharmacological but with physicochemical properties of preparation grossly violate homeostasis tissues. complications at injection s...

The substances of grapes that form the characteristic taste and aroma profile white fortified wine Madeira type were described. use enzyme preparations pectolytic cellulosolytic action Vinozym FCE G Celoviridine Gx20 to intensify extraction phenolic, nitrogen-containing aromatic was proposed. In order deeply oxidize material at stage modernization, heating 65 ° C in a chamber with continuous pu...

Conveying the therapeutic agent to human eye has been a struggling task for formulators and scientists because of complicated arrangement eye. The agents needed deliver drugs specific sites require crossing various ocular barriers, which act as hitches drug delivery. Conventional preparations present in market do not achieve desired results due their lower bioavailability, less retention time, ...

The right atrium including the sinoatrial node was excised from the rabbit heart, immersed in Tyrode's solution, and kept at 0-3 degrees C for several days. The tissue then was warmed to 36-37 degrees C in well oxygenated Tyrode's solution. Transmembrane potentials from cells in the sinoatrial node region and the right atrium were recorded with microelectrodes. After 3 days of storage, the maxi...

The effects of changing the time course of action potential repolarization on the amplitude and coupling interval of delayed afterdepolarizations were studied in small preparations of coronary sinus atrial fibers exposed to catecholamines. Repolarization was accelerated or retarded by current pulses passed through an intracellular microelectrode in the depolarizing or repolarizing direction. Ac...

The effects of changing the time course of action potential repolarization on the amplitude and coupling interval of delayed afterdepolarizations were studied in small preparations of coronary sinus atrial fibers exposed to catecholamines. Repolarization was accelerated or retarded by current pulses passed through an intracellular microelectrode in the depolarizing or repolarizing direction. Ac...