The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines c...

A highly regio- and diastereo-selective synthesis of halogenated C-vinyl glycosides has been achieved from glycals and unactivated aryl acetylenes in the presence of halogenated Lewis acids via a tandem glycosylation-halogenation reaction. The Lewis acid used served the dual purpose of activating the allylic acetoxy group of glycals and serving as halogen source for Markovnikov addition across ...

An efficient approach to a novel family of (Z)-3-amino-3-oxo-1-propenyl selenocyanates was developed based on the reaction KSeCN with 3-trimethylsilyl-2-propynamides in presence ammonium chloride methanol. The accompanied by desilylation process. products were not formed under same conditions absence chloride, which used for first time reactions acetylenes. use this new methodology allowed carr...

Aryl- and hetaryl-substituted acetylenes undergo regio- stereoselective silylzincation by reaction with [(Me3Si)3Si]2Zn in the presence of Et2Zn (10–110 mol%) as additive. The distinctive feature this addition across C?C triple bond is its trans stereoselectivity. radical nature process supported diagnostic experiments DFT calculations, which also corroborate role played steric effects to obtai...

Click chemistry is a modular approach that uses only the most practical and reliable chemical transformations. Its applications are increasingly found in all aspects of drug discovery, ranging from lead finding through combinatorial chemistry and target-templated in situ chemistry, to proteomics and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed 1,2,3-triazole formation ...

We propose an analytic response theory for the density matrix renormalisation group whereby response properties correspond to analytic derivatives of density matrix renormalisation group observables with respect to the applied perturbations. Both static and frequency-dependent response theories are formulated and implemented. We evaluate our pilot implementation by calculating static and freque...

A development of prospective synthetic methods to produce Pyridine including those of complex structure will allow to makes the latter more available and hence Pyridine bases will be widely used in industry. In this paper the Hetrocyclization of Acetylenes with nitriles catalyzed by chromium Complex has been carried out. We have limited our aim to study the chromium catalyzed activation of bifu...