Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around globe. In this disease, chondrocytes responsible for growth and maintenance articular joints start to deplete due rogue involvement phosphoinositide 3-kinase, protein kinase-B p38 mitogenactivated kinases. Presently, there are medications providing symptomatic treatment, however, they cannot t...

conclusions these results showed enhanced muscle atrophy processes following peripheral nerve damage and might provide a useful approach to study underlying muscle mechanisms associated with clinical neuropathic pain syndromes. results compared to control animals, l5 ligated animals developed mechanical and heat hypersensitivity during total period of study. soleus muscle weight as well as cdk5...

Background: Alzheimer’s disease (AD) is the most important neurogenerative disorder with progressive dementia as its main clinical manifestation. The microRNAs (miRNAs) are identified crucial modulators in AD progression. Nevertheless, biological potential of miR-21 obscure. Hence, this study aimed to evaluate possible role pathogenesis via phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/...

The extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAPK) pathway involves a three-step cascade of kinases that transduce signals and promote processes such as cell growth, development, apoptosis. An aberrant response this is related to the proliferation diseases tumors. By using simulation modeling, we document arginine methyltransferase 5 (PRMT5) modulates MAPK thus avo...