Thapsigargin is a non-phorbol ester-type tumor promoter that elevates the intracellular Ca2@ (Ca@2') levels by blocking the microsomal Ca2@ ATPase. At present, the consequence of this Ca@2@ increase and the nature of the tumorigenicity of thapsigargin still remain to be elucidated. Previ ously, we demonstrated that thapsigargin activates the mitogen-activated protein (MAP) kinase via Ca@2' but ...

Thapsigargin is a non-phorbol ester-type tumor promoter that elevates the intracellular Ca2@ (Ca@2') levels by blocking the microsomal Ca2@ ATPase. At present, the consequence of this Ca@2@ increase and the nature of the tumorigenicity of thapsigargin still remain to be elucidated. Previ ously, we demonstrated that thapsigargin activates the mitogen-activated protein (MAP) kinase via Ca@2' but ...

1 Basic Concepts 2 1.1 Terminology and Definitions . . . . . . . . . . . . . . . . . . . . . 2 1.2 Hardy-Weinberg Equilibrium . . . . . . . . . . . . . . . . . . . . 2 1.3 Gametic Equilibrium . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.4 Crossingover and Recombination . . . . . . . . . . . . . . . . . . 3 1.5 Interference . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1...

We have investigated the role of mitogen-activated protein (MAP) kinase in the survival of cerebellar granule cells in primary culture. Brain-derived neurotrophic factor (BDNF) and insulin, but not epidermal growth factor (EGF), promoted the survival of P6 cerebellar granule neurons. BDNF promoted a sustained activation of MAP kinase, whereas that induced by EGF was only transient. Insulin prom...

For machine learning of an input-output function f from examples, we show it is possible to define an a priori probability density function on the hypothesis space to represent knowledge of the probability distribution of f , even when the hypothesis space H is large (i.e., nonparametric). This allows extension of maximum a posteriori (MAP) estimation methods nonparametric function estimation. ...

The Diierential Algebraic Methods, a natural tool for the description and determination of the solution of diierential equations, have proven useful for the computation of aberrations of any desired order in any particle optical system. Besides conventional symplectic systems based on strongly or weakly focusing elements including fringe elds, they also readily allow the treatment of spin dynam...

As nowadays the cartography is unimaginable without computer science, there is more and more need to provide high quality map labeling methods. The arranging of the textual information belonging to the features on the map proved to be a computational hard problem. The traditionally human intelligence based approaches cannot be easily transformed to computer algorithms. Most of the existing appr...