Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar. Approximately 0.5 percent of the clones produced altered heavy chains that: (i) were the same size as or larger than the parent; (ii) no longer recognized by antibody specific for the parent gamma2b subclass...

The influence of MG-191 safener on the uptake, translocation and metabolism of [l4C]acetochlor and [14C]EPTC was studied. The amounts of absorbed radioactivity by maize seedlings at 3, 6, 24, and 72 h after applications of [l4C]labeled herbicides and [l4C]MG-191 were different. Plants treated with [l4C]acetochlor took up 30to 50-fold more radiolabel with­ in 72 h than [14C]EPTCor [14C]MG-191-tr...

In a double-blind parallel group randomised study 191 patients with acute sprains and strains of ankle, hip, shoulder or knees were treated with either 400 mg sulindac or 1200 mg ibuprofen per day for 4 days; of these, 176 completed the trial. Spontaneous pain (day and night), pain on active movement, swelling and tenderness were assessed before and after the treatment period along with a physi...

We previously described a synthetic peptide of myelin proteolipid protein (PLP), peptide 139-151, which induces experimental allergic encephalomyelitis in SJL/J (H-2s) mice. We have now identified an additional determinant, PLP residues 178-191, that is also a potent encephalitogen in this strain. When PLP peptide 178-191 was compared with peptide 139-151 on an equimolar basis, the day of onset...

INTRODUCTION .......................................................................................................................................................181 Reinforcement for the Wall ...................................................................................................................................181 MUREIN, A CROSS-LINKED BIOPOLYMER ....................................

This is a sample chapter of the eBook edition of the above Springer book, from their series Graduate Texts in Mathematics, vol. 173. In the English and German edition, the cross-references in the text and in the margins are active links. In this sample chapter, only those links will work that take you to another location in this chapter.

Recent work applied Dirichlet Process Mixture Models to the task of verb clustering, incorporating supervision in the form of must-links and cannot-links constraints between instances. In this work, we introduce an active learning approach for constraint selection employing uncertaintybased sampling. We achieve substantial improvements over random selection on two datasets.

Gene regulatory interactions are context dependent, active in some cellular states but not in others. Stochastic fluctuations, or ‘noise’, in gene expression propagate through active, but not inactive, regulatory links1,2. Thus, correlations in gene expression noise could provide a noninvasive means to probe the activity states of regulatory links. However, global, ‘extrinsic’, noise sources ge...

Online social networks(OSNs) become important platforms of information diffusion. People forward links pointing to interesting content, and share them with friends. Browsing links is generally considered as the previous step for forwarding links. However, few studies have confirmed this hypothesis before. The deep understanding of forwarding links can help OSNs to improve current forwarding mec...