Hyperbilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common clinical diagnoses in both premature and term newborns. Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental ...

  Background: Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications. The aim of this study was to determine and compare pre-operative total and direct bilirubin levels in cases of simple and perforated acute appendicitis in order to improve the clinical decision making.   Methods: This prospective observational study included eighty patients who ...

background most therapeutic interventions in acute phase of viral hepatitis b patients are conservative. prostaglandins have absorbed many scientists' attention for improving these patients condition, therefore, the present study was designed to evaluate misoprostol (pge1 analogue) effect on acute phase of viral hepatitis b. materials and methods a randomized matched controlled clinical trial w...

Objective Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim this study is to evaluate factors associated with hyperbilirubinemia in infants from western part Guangdong Province, and assess contribution G6PD jaundice. Methods term People's Hospital Yangjiang June 2018 July 2022 were recruited for retrospective analysis. All underwent q...

Acute encephalopathy is classified into multiple syndromes, such as acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and acute necrotizing encephalopathy (ANE), characterized radiologically by lesions in the cerebral subcortical white matter, splenium of the corpus callosum and bil...

In severe and rapidly increasing jaundice, the use of intensive phototherapy provides greater effectiveness and a faster decrement in bilirubin levels compared to conventional phototherapy. The aim of this study was to compare the effectiveness of two types of intensive phototherapy: intensive compact fluorescent tube (CFT) and intensive light-emitting diode (LED) phototherapy. Forty-three infa...

Introduction: Jaundice is an important problem during neonatal period. When total serum bilirubin (TSB) level exceeds a critical limit, it crosses the blood brain barrier and results into bilirubin encephalopathy. The main aim of therapy for neonatal hyperbilirubinemia is prevention of bilirubin encephalopathy by phototherapy and/or exchange transfusion. The aims of this study were to evaluate ...

conclusions the assessment of plasma il-10 levels in chronic hepatitis b acute exacerbation may provide an early predictive marker for progression to hbv-aclf. results il-4, il-12p70 and ifn-γ were undetectable; il-1β, il-6, il-8, il-10 and tnf-α levels were significantly higher than in nc. moreover, cytokines reached the highest levels in acute exacerbation of chb, with the exception of il-2 a...

We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a maximum level of 39 mg/dL at 32 hours of life. Prior to an emergent exchange transfusion, the patient's diagnostic evaluation was significant for Coombs-negative microangiopathic hemol...