BACKGROUND Patients with acute coronary syndromes have elevated plasma levels of the proinflammatory, prothrombotic cytokine CD40 ligand (sCD40L). Statins inhibit CD40L signaling in vitro, but there are no prospective studies of statins and sCD40L in acute coronary syndromes. METHODS AND RESULTS We measured sCD40L in subjects with an acute coronary syndrome enrolled in the Myocardial Ischemia...

a meta-analysis of all major randomised clinical trials. Lancet 2002;359:189–198. 15. Lim MJ, Eagle KA, Gore JM, Anderson FA Jr, Dabbous OH, Mehta RH, Granger CB, Fox KA, Spencer FA, Goldberg RJ. Treating patients with acute coronary syndromes with aggressive antiplatelet therapy (from the Global Registry of Acute Coronary Events). Am J Cardiol 2005;96:917–921. 16. Alexander KP, Chen AY, Newby ...

OBJECTIVE To describe the improvements in care that have followed the introduction of an electronic data entry and analysis system providing contemporary feedback on the management of acute coronary syndromes in 230 hospitals in England and Wales. DESIGN Observational study METHODS A secure electronic system was used to transfer encrypted data on patients with acute coronary syndromes from ...

Objective Recent studies reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and severity of acute coronary syndromes. Methods One hundred and eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes (ACS) were enrolled in the study. Level of P-s...

Spontaneous coronary artery dissection is a very rare cause of acute coronary syndromes and can be life threatening given the rarity of the condition. It should be part of differentials in young females presenting with acute coronary syndromes without routine risk factors for coronary artery disease, especially before, during, and after pregnancy. It is closely associated with fibromuscular dys...