Wilson's disease (WD) is an autosomal recessive disorder. It is characterized by toxic accumulation of copper mainly in the liver and brain but also in cornea and kidney due to a defect in biliary excretion of copper. The hepatic manifestation of WD is diverse and may include asymptomatic elevation of aminotransferase, chronic hepatitis, cirrhosis, or acute/fulminant hepatic failure. Characteri...

introduction: we intended to assess the accuracy of re-expressed modification of diet for renal disease (mdrd) and cockcroft-gault (cg) equations to estimate glomerular filtration rate (gfr) in chronic kidney disease in two different etiologies of acute renal failure (arf): acute tubular necrosis (atn) and acute glomerulonephritis (agn). methods: patients admitted for arf or the patients compl...

BACKGROUND The pathomechanism of acute hepatorenal syndrome (HRS), a particular form of acute renal failure that occurs in the course of acute liver injury, is still poorly understood. The aim of our study was to estimate the influence of the activation and inhibition of the nitric oxide pathway on the water/sodium balance and development of acute renal failure in the course of HRS. MATERIAL ...

background: acute renal failure describes as a syndrome by rapid decline in the ability of the kidney to eliminate waste products, regulate acid–base balance, and manage water homeostasis. when this impairment is prolonged and entered chronic phase, erythropoietin secretion by this organ is decreasing and toxic metabolic accumulates and causes hematological changes include decrease of hct, mcv ...

Acute liver failure (ALF) is a medical emergency requiring immediate evaluation for liver transplantation. We describe an unusual case of a patient who presented with ascites, jaundice, and encephalopathy and was found to have ALF due to natural killer (NK)-like T cell leukemia/lymphoma. The key immunophenotype was CD2+, CD3+, CD7+, CD56+. This diagnosis, which was based on findings in the peri...

background the transjugular intrahepatic portosystemic stent-shunt (tipss) builds a shortcut between the portal vein and a liver vein, and represents a sophisticated alternative to open surgery in the management of portal hypertension or its complications. objectives to describe clinical experiences with a low-profile nitinol stent system in tipss creation, and to assess primary and long-term s...

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE. In acute liver failure, brain edema contributes to an increase in intracranial pressure, which can fatally lead to brain stem herniation. In chronic liver disease, intracranial hypertension is ...

An ideal therapy for acute liver failure (ALF) would be the successful promotion of liver regeneration, with spontaneous recovery from the disease. However, in spite of advances in our understanding of the process of regeneration1 and potential candidate compounds for clinical testing,2 we currently lack the ability to influence this process in the patient with ALF. Thus, therapeutic efforts ar...

Fulminant hepatic failure, a life threatening condition induced by massive hepatocellular necrosis may be associated with significant morbidity and mortality. A better understanding of the pathophysiology of this condition, associated with advances in intensive care management and liver transplantation have improved outcomes. This review describes recent advances in the management of fulminant ...

Acute liver disease presenting as jaundice is a common event occurring in pregnancy occurring in about 1 per 1000 deliveries. The most common cause of jaundice in pregnancy is viral hepatitis. In the developed world viral hepatitis causes about 2/3 s of cases of jaundice in several series. [1] The great majority of viral hepatitidies are of slow onset and course. They are rarely associated with...