Busulfan 16 mg/kg and cyclophosphamide 120 mg/kg were used as conditioning prior to allogeneic marrow transplantation in 50 adult patients with acute nonlymphocytic leukemia (ANLL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML). A standard risk group of 20 patients included those with acute leukemia in remission and CML in chronic phase. A high-risk group of 30 patien...

Common acute lymphocytic leukemia antigen (CALLA' ; CD10) is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) (references 1-8) . It is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL, and is absent from normal PBMC. However, CALLA is not restricted to leukemic cells and is found on a variety of normal tissues (9-14) . ...

Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.

BACKGROUND Exaggerated reaction to insect bites, mainly to mosquitoes, is infrequently described in patients with chronic lymphocytic leukemia. Skin lesions usually appear months to years after the diagnosis of leukemia and are unrelated to laboratory findings, disease course, or therapy. OBSERVATIONS We describe 8 patients with various hematologic disorders (chronic lymphocytic leukemia, acu...

BACKGROUND Knowledge concerning the clinical and biological presentation, as well as the outcome of treatment, of biphenotypic acute leukemia in children is limited. DESIGN AND METHODS This retrospective review analyzes the clinical features and outcome of children with biphenotypic acute leukemia diagnosed and treated over an 8-year period. According to the EGIL scoring system 24 (3.7%) of 6...

conclusions it was demonstrated that the presence of del6q21 in b-cll patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease. results deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings...

Acute polyneuropathy in children with acute lymphoblastic leukemia is extremely rare, but its onset and association with Guillain-Barré syndrome presents a diagnostic challenge. We report a 5-year-old boy who presented with inability to walk during induction chemotherapy for acute lymphoblastic leukemia. Subsequently he developed painful penile erections, difficulty urinating and swallowing. Be...

This paper presents a study on classification of blasts in acute leukemia blood samples using artificial neural network. In acute leukemia there are two major forms that are acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL). Six morphological features have been extracted from acute leukemia blood images and used as neural network inputs for the classification. Hybrid Multila...

Cell surface expression of the T-cell receptor (TCR)/CD3 complex on the cells from 11 acute type adult T-cell leukemia (ATL) and 4 lymphoma type ATL patients was examined by flow cytometry. Cells from 10 of 11 acute ATL patients were TCR alpha beta+ and CD3+, and their mean fluorescence intensities were low (TCR alpha beta, 25.3-84.6; CD3, 22.8-87.8). Cells from two of four lymphoma type ATL di...