Bone loss after spinal cord injury leads to increased fragility of bone and subsequent risk for low-trauma fractures in the sublesional parts of the body. Although in such injuries upper limbs are normally innervated, bone loss may occur in the upper extremities. The present study was designed to determine the systemic effects of spinal cord injury on the fracture healing of upper limbs in rabb...

One third of all spinal injuries involve cervical vertebrae, and the impact of injury to the cervical spinal cord is profound and requires systemic treatment. The role and timing of surgical decompression after an acute spinal cord injury (SCI) remains one of the most controversial topics pertaining to spinal surgery. Lack of controlled, prospective, multicenter clinical studies has contributed...

obesity is one of the most prevalent diet-related problems and increases the risk for diabetes mellitus, hypertension, atherosclerosis and dyslipidemia. cardio vascular disease is a major cause of morbidity and mortality in spinal cord injury (sci) patients. increased fat mass has also been identified as an important risk factor in chronic sci and weight management is recommended as a key cardi...

traumatic central nervous system injuries lead to a severe and permanent neurological deficit. oligodendrocytes (olcs) are vulnerable to damage in a variety of neurologic diseases. although no effective therapeutic option is currently available, recent other studies have shown that cell therapeutic strategies hold promise to enhance functional recovery after injury. the aim of this study is to ...

background: spinal cord injury (sci) imposes a significant burden on the social and marital life. here, we assessed the divorce rate and changes in marital status among a sample of iranian individuals with sci. methods: referred patients to brain and spinal cord injury research center were invited to participate in this cross-sectional investigation. the main exclusion criteria were coincidenta...

introduction: worldwide, every year, many people undergo spinal cord injury which is of the worst health problems and is followed by several secondary complications. today, more than half of the world population is in danger of natural disasters such as earthquake, which is one of the causes of spinal cord injuries outbreak. earthquake in bam also caused many spinal cord injured people for whom...

materials and methods: young adult sprague-dawley rats (200-250g) were assigned into one of the three different groups of control, sci, and adenovirus transfer (ad) (n=3/ group). control rats received no injury, nor any surgery. for sci rats, sci was produced by a 10g brass rod with a tip diameter of 2 mm which was dropped from a height of 12.5 mm onto exposed spinal cord at level of t10 with n...

Traumatic spinal cord injury is one of the important causes of disability.in some of vertebral fractures,spinal canal is deformed and compromised.the relationship between the shape of the cervical canal and spinal cord hnjury has been proved but such a correlation for thoraculombar spine 50 patients with compromised canal(cases) and 50 oatients with intact canal were evaluated in the light of s...

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...