Purpose: To develop and validate a fast, sensitive, and simple liquid chromatographic method coupled with tandem mass spectrometry for the determination of the potent tyrosine kinase inhibitor, ninetedanib (NTB) in plasma, utilizing cyclobenzaprine (CBP) as internal standard (IS). Methods: Separation of the two components (NTB and CBP) was performed on a pentafluorophenyl (PFP) reversed phase c...

Objective: The aim of this study was to determine the frequency, etiology, microbiological sen-sitivity and outcomes of nosocomial tracheobronchitis (NTB) in mechanically ventilated patients admitted in surgical intensive care unit. Methodology: A prospective observational study was conducted in the Surgical Intensive Care Unit (ICU), Department of Anaesthesiology, Civil Hospital Karachi from A...

Non-tariff measures as hidden barriers to agricultural trade would not only result in production and welfare distortions due the international relocation of activities along value chain, but also yield subsequent consequences both scale distribution carbon emissions from agri-food system. This paper estimates ad valorem equivalents non-tariff using a gravity model combination with detailed bila...

Management practices are needed to reduce dryland soil CO(2) emissions and to increase C sequestration. We evaluated the effects of tillage and cropping sequence combinations and N fertilization on dryland crop biomass (stems + leaves) and soil surface CO(2) flux and C content (0- to 120-cm depth) in a Williams loam from May to October, 2006 to 2008, in eastern Montana. Treatments were no-tille...

BACKGROUND Precise designation of high risk forms of latent Mycobacterium tuberculosis-M.tb infections (LTBI) is impossible. Delineation of high-risk LTBI can, however, allow for chemoprophylaxis and curtail majority cases of active tuberculosis (ATB). There is epidemiological evidence to support the view that LTBI in context of HIV-1 co-infection is high-risk for progression to ATB relative to...

The present article examines the role that the need to belong (NTB) plays in people's judgments of personal and group discrimination and in the attributions people make for potentially discriminatory evaluations. The authors hypothesized that the NTB motivates people to conclude that (a) whereas they rarely experience personal discrimination, (b) their fellow in-group members do experience disc...

Resistance to tuberculosis (TB) is cell-mediated but a humoral response is common and may be correlated with the lack of effective local cellular defense mechanisms. The goal of the study was to evaluate IgG, IgA, and IgM-mediated humoral immune response against 38-kDa+16-kDa and 38-kDa+lipoarabinomannan (LAM) mycobacterial antigens in bronchoalveolar fluid (BALF) from patients with pulmonary T...