Inherited deficiency of adenosine deaminase (ADA) results in one of the autosomal recessive forms of severe combined immunodeficiency. This report discusses 2 patients with ADA deficiency from different families, in whom a possible reverse mutation had occurred. The novel mutations were identified in the ADA gene from the patients, and both their parents were revealed to be carriers. Unexpected...

abstract background: the aims of this study were to assay the activity of adenosine deaminase (ada) in estrogen receptor positive (mcf-7) and negative (mda-mb468) breast cancer cell lines. methods: mda-mb468 and mcf-7 breast cancer cell lines were cultured in complete medium, striped serum with and without 0.0 1~-lm diethylstilbestrol (des), complete medium in the presence and absence of 111m t...

Scientists and researchers still question safety and reliability of various Advanced Driver Assistance (ADA) systems. One of the central issues remaining is the interaction of ADA equipped vehicles with other road users. Meanwhile, the first ADA systems have been introduced into the marked. This paper presents a framework for a study to get towards a controlled implementation of new or redesign...

The inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) is a ligand-gated intracellular Ca(2+) release channel that plays a central role in modulating cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)). The fungal metabolite adenophostin A (AdA) is a potent agonist of the InsP(3)R that is structurally different from InsP(3) and elicits distinct calcium signals in cells. We have investig...

Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals. In Escherichia coli, the Ada response involves expression of four genes: ada, alkA, alkB, and aidB. In Pseudomonas putida, the organization of Ada regulon is different, raising questions ...

BACKGROUND A statistical audit of adenosine deaminase (ADA) in pleural effusions was undertaken. METHODS ADA analysis, cytological and microbiological examinations, and differential cell counts were performed on 462 pleural fluid samples. RESULTS ADA activity in tuberculous effusions was higher than in any other diagnostic group. At a level of 50 U/l the sensitivity and specificity for the ...

The GNu Ada Runtime Library (GNARL) is being developed to support Ada 9X tasking for the Gnu NYU Ada Translator (GNAT). Together, they form a portable, freely distributable Ada 9X translation system. GNARL and GNAT communicate through a well-deened procedural interface, facilitating their independent development. Among the design goals of this translation system are portability, interoperabilit...