Co-targeting strategies strive to improve cancer outcomes by combining therapies under contextualized genetic and environmental conditions that selectively target exploitable alterations in tumor cells. Adaptive survival pathways triggered by inhibition of driver genes in the androgen receptor (AR) or PI3K/AKT pathways are of great interest, since they are among the most frequently altered in c...

background: ˝radioadaptive response˝ is well-documented phenomenon appeared in low dose ionizing radiation received in vitro and in vivo. occupational exposure has always been a great concern for radiation workers therefore this study was performed to study radioadaptive response in terms of residual dna double strand breaks as an endpoint in peripheral blood leukocytes of occupationally expose...

Abstract Historical influenza pandemics and the SARS-CoV-2 pandemic revealed gender differences in morbidity of respiratory virus infections. In human or murine A (IAV) infection, females reproductive age generate stronger innate adaptive antiviral responses leading to immunopathology, while elderly males often experience more severe disease. Sex hormone levels play a role this disparity, yet l...

We investigated whether hyperosmolar saline (HS), applied via paper disk onto the septum of one nostril, induces a nasal secretory response. Furthermore, we examined whether this response is accentuated in patients with active allergic rhinitis (AR) compared with healthy volunteers. Unilateral HS produced significant nasal secretions both ipsilateral and contralateral to the site of challenge i...

BACKGROUND The androgen receptor (AR) plays important roles in the development of male phenotype and in different human diseases including prostate cancers. The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR proliferative response program has been well studied, but its prohibitive response program has not yet been thoroughly studied. METHODOLOGY/PRINCIPA...

The mechanisms underlying the blunted contractile response to -adrenergic receptor ( -AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to -AR subtype–specific regulation of L-type Ca channels. We evaluated the impact of HF induced by pacing tachycardia on -AR regulation of L-type Ca channels in a canine model. To evaluate changes in the relative subcellu...

Exaggerated response to alpha2-adrenergic receptor (alpha2-AR) blockade by yohimbine in normotensive subjects is an intermediate phenotype that predicts increased risk for development of hypertension. Here, we assessed the 3 alpha2-AR loci (alpha2A, alpha2B, alpha2C) as candidate genes for their influence on baseline and yohimbine-mediated increase in mean arterial pressure. Because initial res...

The present studies extend recent findings that mice null for the alpha(2A) adrenergic receptor (alpha(2A) AR KO mice) lack suppression of exogenous secretagogue-stimulated insulin secretion in response to alpha(2) AR agonists by evaluating the endogenous secretagogue, glucose, ex vivo, and providing in vivo data that baseline insulin levels are elevated and baseline glucose levels are decrease...

This paper proposes tangible interfaces and interactions for authoring 3D virtual and immersive scenes easily and intuitively in tangible augmented reality (AR) environment. It provides tangible interfaces for manipulating virtual objects in a natural and intuitive manner and supports adaptive and accurate vision-based tracking in AR environments. In particular, RFID is used to directly integra...