We previously showed that the 12/15-lipoxygenase (12/15-LO) pathway of arachidonate acid metabolism is involved in multiple events related to diabetic nephropathy (DN), including glomerular hypertrophy and extracellular matrix deposition (Kang SW, Adler SG, Nast CC, LaPage J, Gu JL, Nadler JL, Natarajan R. Kidney Int 59: 1354-1362, 2001; Kang SW, Natarajan R, Shahed A, Nast CC, LaPage J, Mundel...

Wnts are secreted cysteine-rich glycoproteins with diverse roles in animal development (reviewed in Cadigan and Nusse, 1997). Frizzled proteins are cell surface Wnt receptors characterized by an extracellular cysteine-rich domain (CRD) followed by seven transmembrane segments (Vinson et al., 1989; Wang et al., 1996). Members of both protein families have been conserved in species as evolutionar...

In 1973 Herbert M. Adler coauthored a paper that marked a watershed in the literature on the placebo response.' Since 1945 others had commented upon the placebo effect as it was revealed in research settings through the use of doubleblind studies. Adler and Hammett tied this new line of research to lessons taught in a few classic articles from an earlier era." They showed, first, that cross-cul...

Two forms of leishmaniasis are endemic to the Jenin district in the northern region of the West Bank. Visceral leishmaniasis (VL), caused by Leishmania infantum, mainly affects infants. Cutaneous leishmaniasis (CL) affects a broader age group and is probably caused by L. tropica. Although the Jenin district is the most important focus of leishmaniasis in the West Bank, the sand fly fauna of the...

Adler’e göre insan davranışının oluşumunda kalıtımsal faktörler kadar sosyal çevre, bireyin çevresiyle yaptığı etkileşimler ve etkileşim süreci içinde fenomonolojik anlamlandırmaların da önemi vardır. Adler Kuramı’na birey seçicidir, tektir, karar alabilen hayatını şekillendirebilen bir varlıktır. İnsanın temel amaçları yaşamsal görevlerine değinilen kuramda; bireylerdeki organ eksikliği, aşağı...

We obtain an extension of the Christoffel–Darboux formula for matrix orthogonal polynomials with a generalized Hankel symmetry, including the Adler-van Moerbeke generalized orthogonal polynomials.