نتایج جستجو برای: adme
تعداد نتایج: 990 فیلتر نتایج به سال:
Reviewed by Balaji Agoram For more than a decade, clinical pharmacology (CP), absorption-distribution metabolism, and excretion (ADME), and pharmacokineticspharmacodynamics (PKPD) properties of biologics have received particular attention from experts within the field through increasing numbers of publications and the occasional book dealing with general aspects of CP or PK science. While these...
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups were not required for high antimalarial potency, but they were essential for high antimalarial efficacy in P. berghei-infected mice. Five new ozonides with antimalarial efficacy and ADME profiles sup...
A successful, efficacious and safe drug must have a balance of properties, including potency against its intended target, appropriate absorption, distribution, metabolism, and elimination (ADME) properties and an acceptable safety profile. Achieving this balance of, often conflicting, requirements is a major challenge in drug discovery. Approaches to simultaneously optimizing many factors in a ...
Objectives: Psoriasis is a type of skin disease which accompanied with over production keratinocytes, itchiness, and scaly skin. In this study, an attempt was made to recognize naturally occurring phytocompounds from the plant Curcuma longa can be helpful in treating psoriasis using molecular docking techniques. Methods: The protein associated mechanism obtained data bank database, along retrie...
This work reports on a complex in silico assessment of the ADME properties Salubrinal (S1) and 54 its structural analogues containing cinnamic acid residue (S2–S40) or quinoline ring (S41–S55). In for (Q)SAR forecast, online servers SwissADME, ADMETlab, admetSAR 2.0, Molinspiration, ALOGPS 2.1, pkCSM, SuperCYPsPred, Vienna LiverTox were used. addition, using AutoDock Vina, molecular docking stu...
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