The involvement of catecholamines in stress-induced heart injury is well documented. However, the contribution of adrenergic receptor types is less understood. Both the profile of plasma marker enzyme activities (lactate dehydrogenase-1 and aspartate transaminase) and the distribution and morphology of the lesions observed in tissue sections of adrenaline-injected mice resembled those of stress...

The present study was designed to investigate the interaction between neuroendocrine mediators and the immune system in chronic fatigue syndrome (CFS). We examined the sensitivity of the immune system to the glucocorticoid agonist dexamethasone and the beta2-adrenergic agonist terbutaline in 15 adolescent girls with CFS and 14 age- and sex-matched controls. Dexamethasone inhibits T-cell prolife...

Rationale: The ? 2 -adrenoceptor (? -AR), a prototypical GPCR (G protein-coupled receptor), couples to both G s and i proteins. Stimulation of the -AR is beneficial humans animals with heart failure presumably because it activates downstream -PI3K-Akt cell survival pathway. Cardiac signaling can be regulated by crosstalk or heterodimerization other GPCRs, but physiological pathophysiological si...

Whether large coronary artery dilation induced by /3-adrenergic stimulation is mediated by /3ior /32adrenergic receptors remains controversial. This problem is particularly difficult to address in vivo due to the concomitant increase in coronary blood flow with /3-adrenergic stimulation, which by itself can dilate large coronary arteries. To reconcile this problem, 5 calves were instrumented wi...

Agonist-independent properties of the human f32-adrenergic receptor (fl2AR) were studied using the baculovirus expression system in Sf9 cells. In the absence of agonist but in the presence of GTP, membranes from cells expressing the fl2AR exhibited higher levels of cAMP production than did membranes from uninfected cells or from cells infected with wild-type baculovirus. The increase in cAMP pr...

Suggestions to Contributors Tribute to Dr. Paul Lewis Munson 3 Agonist-induced Desensitization of the 3-Adrenergic Receptor-linked Adenylate Cyclase. T. KENDALL HARDEN 5 Behavioral and Pharmacological Aspects of Opioid Dependence: Mixed Agonist-Antagonists. WILLIAM L. WOOLVERTON AND CHARLES R. SCHUSTER 33 Pharmacology of Mesocortical Dopamine Neurons. MICHAEL J. BANNON AND ROBERT H. ROTH 53 Opi...

The presence of sex differences in myocardial β-adrenergic responsiveness is controversial, and limited studies have addressed the mechanism underlying these differences. Studies were performed using isolated perfused hearts from male, intact female and ovariectomized female mice to investigate sex differences and the effects of ovarian hormone withdrawal on β-adrenergic receptor function. Fema...

Abstract Introduction Smith-Magenis syndrome (SMS) is a rare disorder associated with several genetic mutations. Patients SMS experience circadian rhythm sleep-wake disorders, which may lead to significant behavioral concerns. A proposed etiology of sleep disturbances diurnal melatonin secretion. Treatment approaches aim at blocking the abnormal morning secretion and providing exogenous in even...

A novel thiadiazole compound, SCH-202676 (N-(2,3-diphenyl-1,2, 4-thiadiazol-5-(2H)-ylidene)methanamine), has been identified as an inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs). SCH-202676 inhibited radioligand binding to a number of structurally distinct, heterologously expressed GPCRs, including the human mu-, delta-, and kappa-opioid, alpha- and beta...