Lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) are highly prevalent in older men. The storage subcategory of LUTS is synonymous with overactive bladder syndrome (OAB) which is an empirical diagnosis. Traditionally, alpha-blockers are widely prescribed to manage LUTS of BPH, although storage symptoms may persist in many men despite treatment. Therefore, since therapie...

Single oral doses of propranolol (120 mg), metoprolol (150 mg) and placebo were given in a randomised, double-blind fashion to 23 patients with essential tremor. Both beta blockers were significantly more effective than placebo in reducing the magnitude of tremor. The decrease in tremor produced by metoprolol (47, sem 9%, n = 23) was not significantly different from that observed propranolol (5...

Rabbits infected with Schistosoma japonicum either bior monosexually, were clinico-pathologically examined and observed for effects of adreno-cortical hormone on the clinico-pathological findings. Either evaluation or extraction of the fragment of serum protein was performed by electrophoresis on filter paper or starch. Fractions of the serum protein were classified by the difference in specifi...

Carney complex (CNC) is an inherited neoplasia syndrome with endocrine overactivity. Its most frequent endocrine manifestation is primary pigmented nodular adrenocortical disease (PPNAD), a bilateral adrenocortical hyperplasia causing pituitary-independent Cushing's syndrome. Inactivating mutations in PRKAR1A, a gene encoding the type 1 alpha-regulatory subunit (R1alpha) of the cAMP-dependent p...

PURPOSE Cell-to-cell communications between the epithelial layers of the ciliary body may be critical for aqueous humor production. The aim of this study was to identify pharmacologic agents that affect this path. METHODS Whole New Zealand rabbit ciliary bodies were mounted in Ussing-type chambers with Ca2+(-)free and Ca2+(-)rich Tyrode's in the nonpigmented (NPE; aqueous) and pigmented (PE; ...

We review the crucial role of the two neurotransmitters norepinephrine (NE) and GABA in eliciting GnRH pulse. NE acts via an alpha l-receptor mechanism and also GABA acts at the alpha-subtype of the GABA receptor. The function of NE appears to be induction of phasic activation of GnRH neurons and GABA inhibits GnRH neurons tonically until they are all ready for phasic activation. By an unknown ...

For many years large doses of salicylate have been used in the treatment of acute rheumatic fever (Coburn, 1936, 1943; Manchester, 1946). Although the acute manifestations of the disease are partially suppressed (Illingworth, Burke, Doxiadis, Lorber, Philpott, and Stone, 1954), there is no convincing evidence that chronic damage to the heart is prevented (Bywaters, 1950). However, the introduct...

Nodular hyperplasia or adenomas have been shown to develop in the adrenal glands of certain strains of mice, notably CBA, DBA, BALB, NH, and A, after the removal of their gonads (5, 7, 8, 13, @1). These changes were usually accompanied by the elaboration of either estrogenic or andro genic hormones or both (3, 6). In CE mice, car cinomas developed in 100 per cent of the females and in 97 per ce...

The depressant effect of adrenal steroids on the release of pituitary adrenocorticotrophic hormone (ACTH) was first demonstrated by Ingle in the experimental animal in 1937 (1). This observation has been confirmed by many investigators (2-7), but not by all (8). In man the clinical, morphological and biochemical evidence for steroidal inhibition of pituitary secretion is impressive but there ar...