introduction: radioiodine (131i) is an effective and inexpensive alternative to surgery in the treatment of thyroid hyperfunction. the debate today concerns the maximum and minimum ablative doses, and factors leading to hypothyroidism. patients & method: 1035 hyperthyroid patients treated with weight-adjusted ablative doses of 131i were retrospectively assessed for treatment outcome or corr...

Beckwith-Wiedemann syndrome has a wide spectrum of complications such as embryonal tumors, namely adrenocortical tumor. Tumor predisposition is one of the most challenging manifestations of this syndrome. A 45-day old female with a family history of adrenocortical tumor presented with adrenocortical tumor. The case raised suspicion of a hereditary Beckwith-Wiedemann syndrome, therefore molecula...

Adrenocortical tumors occur as sporadic tumors, as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome or as part of other hereditary disorders. We recently cloned the MEN1 gene, a tumor-suppressor gene located on chromosome 11q13. Subsequently, we showed that sequential somatic inactivation of both alleles of the MEN1 gene contributes to the development of some sporadic endocrine n...

Fifty-eight 10-year old children were recorded and judged by a panel of voice expert listeners, who rated the voices along 26 voice parameters represented by visual analogue (continuous) scales on a test form. Interjudge reliability was high. Rank ordered rating means revealed a discontinuity i n the distribution for most parameters. A factor analysis revealed three factors of major relevance t...

The effects of four endocrine disruptors: resveratrol, diphenylolpropane (bisphenol-A; BSP), benzophenone-3 (BP3) and silymarin on the secretory and proliferative activity of rat adrenocortical cells were investigated in vitro. Resveratrol and BP3 acutely increased basal corticosterone secretion from freshly dispersed adrenocortical cells, and resveratrol and BSP enhanced ACTH-stimulated cells....

OBJECTIVE To analyze the aberrant expression of the GIPR and LHCGR in different forms of adrenocortical hyperplasia: ACTH-independent macronodular adrenal hyperplasia (AIMAH), primary pigmented nodular adrenocortical disease (PPNAD) and diffuse adrenal hyperplasia secondary to Cushing's disease (DAHCD). METHODS We quantified GIPR and LHCGR expressions using real time PCR in 20 patients with a...

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy that arises from the adrenal cortex. It challenging disease to manage due its rarity, variable presentation, lack of effective systemic therapy options. Objectives: The main objective study find impact multimodal on margin status overall survival for patients undergoing adrenalectomy localized adrenocortical carcin...

Adrenocortical cancer is a rare tumor originating from cortical adrenal cells, endowed with aggressive potential, rapidly progressing course and an unfavorable prognosis. The complexity of early diagnosis the disease due to several factors: variability clinical manifestations associated initial multiregulatory influence steroid hormones on body’s homeostasis, occurrence and, as result, lack und...

BACKGROUND Adrenocortical carcinoma is a rare cancer, with an incidence in the literature of 0.5 to 2 cases per million population per year. Adult adrenocortical carcinoma has a poor prognosis, underscoring the importance of identifying diagnostic and prognostic markers. METHODS We searched our laboratory database for all cases in the past 15 years with a diagnosis of adrenocortical carcinoma...