OBJECTIVE Autologous platelet rich plasma is an advanced wound therapy used in hard-to-heal acute and chronic wounds. To better understand the use and clinical outcomes of the therapy, a systematic review of the published literature in cutaneous wounds was performed. METHODS Electronic and hand searches for randomized controlled trials and comparative group studies using platelet rich plasma ...

The opossum delivers a newborn baby equivalent to tremature fetus state by postpregnancy. The peculiarity is advantageous for studies of fetus, because operations to take out fetus from the uterus of a mother are not necessary. When mammalian skin is wounded by full-thickness excision, fetal and adult wound healing processes differ. Fetal-type wound healing does not leave a scar. However, studi...

Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment ...

The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced...

MRS BULLETIN • VOLUME 33 • AUGUST 2008 • www.mrs.org/bulletin Abstract Self-healing polymers have experienced rapid technological advancement over the past seven years. They have moved from a conceptual demonstration to practical application in this time frame and have grown from a single design to a generic paradigm for modern materials development. Potential applications of self-healing polym...

ObjectiveChronic diabetic foot ulcers (DFUs) often experience inadequate healing rates, and alternatives to existing therapies are needed improve the success of wound healing. The objective this clinical study (clinicaltrials.gov number NCT03312595) was evaluate outcomes using a synthetic hybrid-scale fiber matrix for treatment DFUs.MethodsIn prospective multi-center study, chronic DFUs were tr...

High-performance strain sensors featuring self-healing ability and high stretchability are desired for human motion detection, soft robotics, diver intelligent applications. Herein, a novel elastomer was synthesized via facile one-pot polycondensation reaction between bis(3-aminopropyl) terminated polydimethylsiloxane 2,4’-tolylene diisocyanate, followed by introducing carboxyl-functionalized m...

Chronic dermal wounds are a devastating problem, which disproportionally affect individuals with conditions such as diabetes, paralysis, or simply old age. These wounds are extremely challenging to treat due to a heterogeneous combination of causative factors, creating a substantial burden on healthcare systems worldwide. Despite their large impact, there is currently a startling lack of option...

OBJECTIVE The role of the psychiatric advanced practice nurse in promoting psychological health and resiliency for patients, their families and staff following the Boston Marathon bombings is reviewed. BACKGROUND On April 15, 2013, 2 bombs exploded near the finish line at the Boston Marathon. Within minutes, 39 patients suffering from multiple injuries presented at a level I trauma center. Th...

To investigate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in advanced diabetic foot ulcers (DFU) A double-blind trial was carried out to test two rhEGF dose levels in type 1 or 2 diabetes patients with Wagner's grade 3 or 4 ulcers, with high risk of amputation. Subjects were randomised to receive 75 (group I) or 25 mug (group II) rhEGF through intralesional inj...