Bacterial pathogens are becoming more and more resistant to antibiotics used commonly by healthcare practitioners. Despite introduction of new antibiotics, empiric treatment of patients with bloodstream infections (BSIs) became a major challenge for practicing physicians.1,2 To depict the susceptibility patterns of BSI pathogens endemic in a referral pediatric hospital, Children’s Medical Cente...

Zataria multiflora Boiss, known as Avishan-eShirazi in Persian, with traditional pharmacological properties take advantage of being useful medicinal plant. In this study, the chemical composition of different parts of Iranian Z. multiflora Boiss oils and also its antioxidant and antibacterial properties have been considered. The results showed that the main oil components especially thymol and ...

A series of substituted 8-arylazo 7-hydroxy 4-methyl coumarin (4a-4g) were synthesized and in-vitro evaluation for their preliminary antibacterial activities against E.coli, Staphylococcus aurous, Bacillus subtilis and Pseudomonas aeroginosa were carried out by agar-well diffusion method. Initially, the diazotized primary aryl amines, 3a-3g were synthesized and followed by coupling with 7-hydro...

UNLABELLED Development of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Ca...

The microbial source, variety of producing species, functions and an assortment of bioactivities of metabolites. The probable numbers of metabolites may be discovered in the future, the problems of dereplication of recently isolated compounds as well as the new trends and prediction of the research are also discussed. Ten isolates were isolated from different plant parts (root, stem, leaves) of...

Objective: The present study investigates the qualitative and quantitative phytoconstituents and bactericidal effect of medicinally important Pelargonium graveolens L’ Her leaves extracts. Methods: Preliminary phytochemical screening analyses were determined using standard protocol methods. In addition, antibacterial activities of the P. graveolens leaves extracts were evaluated by disc diffusi...

The study was conducted to evaluate a new cefixime-clavulanic acid combination for in vitro susceptibility towards gram-negative bacteria. A total of 220 isolates of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeroginosa, Acinetobacter spp, Salmonella enterica serovar Typhi and Salmonella enterica serovar Typhimurium were included in the study. The isolates were tested for susceptibili...

Bacteria capable of denitrification play a significant role in the nitrogen cycle of freshwater ecosystems. By metabolizing nitrogen compounds they e.g. counteract the eutrophication of natural waters. To get detailed insights into the in situ turnover rates of nitrogen a reliable tool of quantification for active microorganisms is essential. In the present investigation, quantification capabil...

Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibacterial activities against Pseudomonas aeroginosa, Staphylococcus aureus and Ech...

Pathogens resistant to most conventional antibiotics warrant the need to discover novel antimicrobials and develop innovative strategies to combat them. The aim of this study was to assess the in vitro antimicrobial activities of bacteriocins in culture supernatants of vaginal Lactobacilli alone or in combination with conventional antibiotics against Salmonella typhimurium, Pseudomonas aerugino...