The Large-Scale Integrating Project MARK-AGE (“European Study to Establish Biomarkers of Human Ageing”; www.mark-age.eu) was launched in April 2008 and is carried out by 26 research groups from academia, SMEs and industry. The scientific background is the following: The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related ...

The combined effects of electron-beam irradiation and ageing of beef were examined. The irradiated samples at dose of 0 or 2 kGy were kept and analyzed for the microbial growth, shear values, meat color, and nucleotide-related flavor compounds at different ageing temperatures (2, 10, or 25℃) for 8 d. The irradiation effect on inactivation of foodborne pathogens was also investigated. The popula...

A challenge in automatic speaker verification is to create a system that is robust to the effects of vocal ageing. To observe the ageing effect, a speaker’s voice must be analysed over a period of time, over which, variation in the quality of the voice samples is likely to be encountered. Thus, in dealing with the ageing problem, the related issue of quality must also be addressed. We present a...

AIM This paper reports a study whose aims were to introduce the theory of gerotranscendence to a group of older people; to give participants in the group an opportunity to discuss their ageing process; to study how participants described their ageing in relation to the theory; and to gather participants' opinions about discussing their ageing in a group. BACKGROUND The theory of gerotranscend...

Introduction Ageing, old age and death have piqued the interest of philosophers and writers since antiquity. Confucius related ageing to maturity and wisdom,1 while Shakespeare described it as a “second childhood”.2 Cicero, perhaps with premonitions of his own demise, viewed death with fondness in a metaphor, likening it to a ship approaching a harbour.3 Confronted by ageing demographics, Singa...

This review focuses on the interrelationship between ageing and autophagy. There is a striking similarity between the signalling aspects of these two processes. Both ageing and autophagy involve several of the signalling components such as insulin/IGF-1, AMPK, Ras-cAMP-PKA, Sch9 and mTOR. Ageing and ageing-mediated defective autophagy involve accumulation of lipofuscin. Components of anti-agein...

Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, ...

High-throughput genomic and proteomic technologies have generated a wealth of publicly available data on ageing. Easy access to these data, and their computational analysis, is of great importance in order to pinpoint the causes and effects of ageing. Here, we provide a description of the existing databases and computational tools on ageing that are available for researchers. We also describe t...

In this paper, we present a comparative study that focus on Supercapacitor (SC) thermal cycling and calendar ageing under constant voltage tests. The impacts of cycling temperature on SC performance and degradation rate are studied. Obtained results from thermal cycling ageing test are compared with those coming from simple calendar ageing test at constant voltage and constant temperature. The ...

Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on ...