BACKGROUND Marine organisms produce many novel compounds with useful biological activity, but are currently underexploited. Considerable research has been invested in the study of compounds from marine bacteria, and several groups have now recognised that marine fungi also produce an interesting range of compounds. During product discovery, these compounds are often produced only in non-agitate...

OBJECTIVES Exposure to intravascular microbubbles after diving and during medical procedures alters endothelial function. The aim of this study was to investigate whether a patent foramen ovale altered forearm endothelial function by facilitating microbubbles transfer. DESIGN Patients attended on two separate visits, at least seven days apart receiving agitated saline or no active interventio...

Reduction in competence makes older adults with dementia more sensitive to the influence of physical environment. The aim longitudinal study was examine whether residents long-term facilities variability environmental characteristics Vancouver (N=11), Canada and Stockholm (N=13), Sweden had a difference their quality life (QoL). QoL assessed using Dementia Care Mapping (DCM) tool three times ov...

BACKGROUND Ultraviolet (UV) light, especially UVC, is germicidal but its ability to penetrate layers of protein containing solutions is poor. This hampers its use to inactivate pathogens in therapeutic fresh plasma (FP). STUDY DESIGN AND METHODS FP units were spiked with lipid-enveloped or nonenveloped viruses. Others were used without spiking. The units were transferred into UV-transparent b...

Formation of senile plaques containing amyloid fibrils of Aβ (amyloid β-peptide) is a pathological hallmark of Alzheimer's disease. Unlike globular proteins, which fold into unique structures, the fibrils of Aβ and other amyloid proteins often contain multiple polymorphs. Polymorphism of amyloid fibrils leads to different toxicity in amyloid diseases and may be the basis for prion strains, but ...

1. Definition of Catalytic Properties 1.1. Conversion 1.2. Selectivity 1.3. Yield 1.4. Catalyst Deactivation and Sustainability 2. Reactor Types 2.1. Batch Reactor 2.2. Perfectly Mixed Flow Reactor 2.3. Plug Flow Reactor 3. Intrinsic Kinetics 3.1. External Mass and Heat Transport Limitations 3.2. Internal Mass and Heat Transport Limitations 3.3. Flow Pattern Ideality 4. Specific Reactor Types 4...

OBJECTIVE The objective of this study was to examine the efficacy of a systematic algorithm for providing individualized, nonpharmacological interventions for reducing agitated behaviors in nursing home residents with dementia. METHODS This placebo-controlled study combined nomothetic and ideographic methodologies. The study was conducted in 12 nursing home buildings in Maryland; 6 were used ...