Asthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety of endogenous and exogenous stimuli. Many asthma models are used to mimic the human asthma model in the literature. In order to better understand the role of the cannabinoid (CB) 2 receptor in the ovalbumin (OVA)-induced asthma model, a combination of both selective CB2 agonist (AM1241) and...

Background: To compare the effect of GnRH agonist administration with vaginal progesterone on serum progesterone in Luteal phase in control ovarian hyper stimulation and intrauterine insemination cycles Materials and Methods: In this clinical trial, 242 infertile patients because of UEI (unexplained inferetility candidate for ovarian stimulation and intrauterine insemination reffering to infert...

Abstract Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play pivotal roles in cell responsiveness. Dysregulation receptor can lead to aberrant signaling behavior. Here, using an endosomal BRET-based assay a high-throughput screen with the prototypical GPCR angiotensin II type 1 (AT1R), we sought identify inhibitors from library ~115,000 small molecules. We ...

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II (PD42)1 Sep 2021PD42-06 BOOSTING THE COMBINATION OF RADIATION AND ANTI-PD-L1 WITH STING AGONIST IN A PRECLINICAL MUSCLE INVASIVE BLADDER CANCER MURINE MODEL Gautier Marcq, Jiamin Huang, Côme Tholomier, Surashri Shinde-Jadhav, Ronald Kool, Rodrigo Skowronski, Fadi Brimo, Jose Joao Mansure, and Wassim Kassouf Mar...

Microspectrofluorometry of fura-2 was utilized to monitor [Ca2+]i in single acinar cells stimulated with a cholinergic agonist and cholecystokinin. A similar amplitude of agonist induced Ca mobilization between single cell and populational approaches was observed. New findings in single cells not observable in populations of cells include: 1) the maintenance of a sustained elevation in [Ca2+]i ...

Objectives: One of the most common and disabling complications that affects individuals with spinal cord injury is spasticity. The purpose of this study is to compare the effect of agonist and antagonist electrical stimulations on triceps surae muscle spasticity in patients with spinal cord injury. Methods: A total of 30 subjects with spinal cord injury were considered for the study. They were...

Objective To test the selectivity and degree of functional agonism Ocelot Bio’s dual agonist/antagonist molecule, OCE-205, at vasopressin 1a receptor (V1aR). Methods Cells expressing human (h) or rat V1a, V1b, V2, oxytocin receptors (OTR) were incubated with varying concentrations OCE-205 arginine (AVP), responses measured fluorescence reporter gene assays. In addition, resistance arteries expo...

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...

Background: Endometriosis is a chronic disorder characterized by the presence of endometrial tissue outside the uterus. Endometrial cells from retrograde menstruation implant on peritoneal surfaces and elicit an inflammatory response, associated with angiogenesis, fibrosis, neuronal infiltration, and anatomical distortion. Affecting an estimated 176 million women worldwide, the condition is sti...

objective(s) the central nucleus of the amygdala (cea) is a forebrain structure which is important in regulation of ingestive behavior and there is direct and circumstantial evidence to indicate that some circuits involved with feeding behavior include glutamatergic elements. the present study examined whether administration of nma (n-methyl-dl-aspartic acid) or mk801 into the cea altered water...