Cowpea is one of the most consumed legumes in Africa. Recombinant DNA technology has been used to insert foreign genes into plants genome thereby creating a new generation with desired traits. Such possess improved seed quality, yield and resistance pests pathogens. The aim this work assess safety profile an variety cowpea by examining its effect on liver kidney.Native cowpea, IT89KD, were fed ...

Sistiserkosis adalah penyakit infeksi yang disebabkan oleh larva (cysticercus) cacing pita. pada babi Cysticercus Taenia solium berparasit otot, hati, otak, dan mata babi. Bentuk dewasanya ada dalam usus manusia, disebut T. solium. Babi juga dapat terinfeksi hydatigena peritoneum, omentum mesenterium. dewasanya, hydatigena, anjing. berkembang hati menyebabkan kerusakan hati. Tujuan penelitian i...

Introduction Dynamic Nuclear Polarisation (DNP) has recently been shown to increase the sensitivity of C magnetic resonance spectroscopy (MRS) by several orders of magnitude [1]. The number of metabolites that can be hyperpolarized using this technique is increasing; here we show that [1-C]glutamic acid can also be polarized using DNP. The metabolism of hyperpolarized glutamate to αketoglutarat...

The objective of our study was to examine the hepatic protective mechanism of Ginkgo biloba extract (GBE) in rats with obstructive jaundice (OJ). Twenty rats underwent bile duct ligation and received daily intraperitoneal injections of either control saline or Ginkgo biloba extract for 14 days. Ten sham-operated rats had their bile duct exposed but not ligated or sectioned. Serum alanine transa...

We have recently utilized a prototype model of the Beckman Enzyme Activity Analyzer System-TR in our laboratory measuring various serum enzyme activities which include: alkaline phosphatase (ALP), E.C.3.1.3.1; creatine kinase (CK), E.C.2.7.3.2; hydroxybutyrate dehydrogenase (HBD), E.C.1.1.1.30; lactate dehydrogenase (LD), E.C.1.1.1.27; aspartate transaminase (AST), E.C.2.6.1.1; and alanine tran...

Brewers' rice, which is known locally as temukut, is a mixture of broken rice, rice bran, and rice germ. Our present study was designed to identify the effect of brewers' rice on the attenuation of liver and kidney damage induced by azoxymethane (AOM). Alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), creatinine, and urea were evaluated to understand potentia...

BACKGROUND/AIM The need for sensitive biological markers to detect and prove recent drinking has been the focus of many research groups. The aim of our study was to investigate the alterations of biological markers in a population of alcohol dependent individuals during the detoxification period. PATIENTS AND METHODS Fifty-two alcohol-dependent individuals were admitted for alcohol detoxifica...

Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-linked immunosorbent assay, and reverse tr...

Tolcapone and entacapone are catechol-O-methyltransferase (COMT) inhibitors developed as adjunct therapies for treating Parkinson's disease. While both drugs have been shown to cause mitochondrial dysfunction and inhibition of the bile salt export protein (BSEP), liver injury has only been associated with the use of tolcapone. Here we used a multiscale, mechanistic model (DILIsym(®)) to simulat...

AIM To identify significant liver disease [including nodular regenerative hyperplasia (NRH)] in asymptomatic Didanosine (DDI) exposed human immunodeficiency virus (HIV) positive patients. METHODS Patients without known liver disease and with > 6 mo previous DDI use had liver stiffness assessed by transient elastography (TE). Those with alanine transaminase (ALT) above upper limit normal and/or ...