Diabetic nephropathy is the most often complication of diabetes mellitus (DM). Complications diabetic can occur through several pathways, one which formation Advanced Glycation End Products (AGEs) Glycated Albumin (GA). albumin (GA) a medium-term glycemic control (2-3 weeks), shorter duration than HbA1c months). The aim this study was to compare levels GA in T2DM patients with normoalbuminuria,...

Hypoalbuminemia of Hemodialysis (HD) patients is an independent cardiovascular risk factor, however, there is no mechanistic explanation between hypoalbuminemia and vascular injury. In the event of oxidative stress and inflammation to which HD patients are exposed, albumin is oxidized and undetected by common laboratory methods, rendering an apparent hypoalbuminemia. We wanted to show that thes...

Abstract The Maillard reaction is traditionally subdivided into three stages that start consecutively and run in parallel. Here, we show N -ε-carboxymethyllysine (CML), a compound formed the late stage of reaction, can undergo second glycation event at its secondary amino group leading to new class Amadori rearrangement products. When -α-hippuryl-CML was incubated presence reducing sugars such ...

Advanced oxidation protein products (AOPPs) are carried by oxidized plasma proteins, especially albumin and accumulate in subjects with renal disease and coronary artery disease. AOPPs represent an excellent novel marker of oxidative stress and their roles in the development of cardiovascular disease might be of great importance. Here, we show that in vitro-generated AOPP-albumin binds with hig...

BACKGROUND The glycation of human serum albumin (HSA) during diabetes can affect the ability of this protein to bind drugs and small solutes in blood. This study describes the use of (16)O/(18)O-labeling and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to compare the levels of modification that occur throughout HSA under various glycation conditions in vitro. The...