ALTHOUGH its histological features had long been recognized (1). the term non-alcoholic steatohepatitis (NASH) was first used by Ludwig et al. as recently as 1980 (2). Although it is commonly encountered in hepatology outpatient (office) practice (3). surprisingly little attention has been paid to NASH. It will be the purpose of this review to examine the clinical and pathological features of N...

AIMS To determine whether the functional A49G polymorphism of cytotoxic T-lymphocyte antigen-4 (CTLA-4), a T-cell surface molecule that modulates T-lymphocyte activation and influences the risk of developing alcohol-induced autoantibodies, plays a role in susceptibility to alcoholic liver disease (ALD) and influences disease severity in Italian alcohol abusers. METHODS One hundred and eighty-...

Apoptosis occurs in the normal liver and in various forms of liver disease. The CD95 (APO-1/Fas) (CD95) receptor mediates apoptosis, and liver cells in animal models are acutely sensitive to apoptosis initiated by this receptor. We have used primary human hepatocytes as a model system to investigate CD95-mediated apoptotic liver damage. Treatment of fresh human hepatocytes with low concentratio...

Introduction Chronic liver disease is responsible for about 800,000 deaths a year due to cirrhosis and its complications. The most common causes of liver disease worldwide are viral hepatitis, chronic alcohol consumption, and non-alcoholic fatty liver disease (NAFLD) associated with the metabolic syndrome. All these conditions generate liver injury and inflammation, thereby activating liver fib...

Background. Alcoholic liver disease is a major cause of liver cirrhosis and the hepatorenal syndrome is a serious complication. Risk factors for hepatorenal syndrome (HRS) in alcoholic liver cirrhosis are not entirely explored. Aim. To assess the risk factors for hepatorenal syndrome in alcoholic liver cirrhosis. Patients and Methods. Consecutive patients with alcoholic liver disease were follo...

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes diseases: 25% population European countries have signs NAFLD, 10–20% patients with steatosis develop an inflammatory process (non-alcoholic steatohepatitis), which, if not treated, can transform into fibrosis and cirrhosis. In people, NAFLD diagnosed, prognosis inaccurate, there are no licensed methods treating disease. ...

Using hepatic vein catheterization, fractional clearance (K) and hepatic extraction rate (ER) of Indocyanine Green (ICG) and radioisotope particles (RI) were studied in cirrhotic portal hypertension (24 postnecrotic cirrhotics and 25 alcoholic cirrhotics). ICG given intravenously is cleared from blood only by hepatocytes, whereas RI are uptaken by intrahepatic (Kupffer cells) and extrahepatic r...

To the Editor: Oxidative stress, which can be induced by iron overload, may play a pivotal role in the pathogenesis of alcoholic liver disease (ALD) which is characterized by fatty liver, hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma (1). Increasing evidence indicates that ALD is a multifactorial disease in which both environmental and multiple genetic factors play a role. The hem...

Abstract Background Alcohol-related liver disease (ALD) is a major cause of chronic diseases. Inflammatory response basic pathological feature ALD. Mucosal-associated invariant T(MAIT) cells are novel population innate immune cells, which may be depleted in various inflammatory However, the changes MAIT cell ALD remains unclear. Results In this study, levels were significantly decreased patient...

The syndrome of cirrhotic cardiomyopathy, first recognized in 1969 but mistakenly presumed to reflect latent alcoholic cardiomyopathy in patients with alcoholic cirrhosis, is now recognized to occur in all forms of cirrhosis, alcoholic and non-alcoholic, and thus is associated with cirrhosis per se. The hallmark of the syndrome is normal or increased ventricular contractility at rest, but depre...