The fireworks from the spectacular emergence of Notch as the protagonist in the etiology of T-ALL are not likely to end any time soon. Indeed, in this issue of Blood, Sulis and colleagues describe yet another sophisticated mechanism by which ligand-independent activation of NOTCH1 is achieved in T-ALL. NOTCH1activating mutations mark more than half of all T-ALL cases, underscoring the fundament...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...